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This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Antibodies to this protein (and modification) were previously sold as part of a Thermo Scientific Cellomics High Content Screening Kit. This replacement antibody is now recommended for researchers who need an antibody for high content cell based assays. It has been thoroughly tested and validated for cellular immunofluorescence (IF) applications. Further optimization including the selection of the most appropriate fluorescent Dylight conjugated secondary antibody may have to be performed for your high content assay.
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with the phosphorylated forms of either p42/44 MAPK or SAPK/JNK.
MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CG7393-PA; CRK1; CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug binding protein 1; Cytokine suppressive anti-inflammatory drug-binding protein; cytokine-supressive anti-inflammatory drug binding protein; EC 2.7.11.24; ERK1; LD24658p; MAP 14; MAP kinase 14; MAP kinase 2; MAP kinase MXI2; MAP kinase p38; MAP kinase p38 alpha; MAP kinase p38alpha; MAP kinase p38b; MAPK 14; MAPK1 antibody; MAX-interacting protein 2; mitogen activated protein kinase 14; Mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase p38b; MK14; OTTHUMP00000216563; OTTHUMP00000216566; p38 alpha; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38 mitogen-activated protein kinase; p38alpha Exip; p38b-PA; reactive kinase; RP1-179N16.5; SAPK2a; stress-activated p38b MAP kinase; Stress-activated protein kinase 2a; tRNA synthetase cofactor p38
Gene Aliases: 186F5S; anon-sts23; BG:DS00797.3; CG7393; CRK1; CSBP; CSBP1; CSBP2; CSPB1; D-p38; D-p38 MAPK; D-p38b; Dm p38b; Dmel\CG7393; Dmel_CG7393; Dmp38b; Dp38; Dp38b; ESTS:186F5S; EXIP; Hog; MAPK; MAPK14; Mpk34C; MXI2; P38; p38 beta; p38 MAPK; p38-alpha; p38a; p38ALPHA; p38B; p38beta; p38Hog; p38Kb; p38MAPK; PRKM14; PRKM15; RK; SAPK2A
UniProt ID: (Human) Q16539, (Mouse) P47811, (Fruit fly) O61443
Entrez Gene ID: (Human) 1432, (Pig) 100156630, (Rat) 81649, (Mouse) 26416, (Fruit fly) 34780
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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