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Invitrogen
Phospho-p38 MAPK beta (Thr180, Tyr182) Recombinant Rabbit Monoclonal Antibody (RM243)
FIGURE: 1 / 2
Phospho-p38 MAPK beta (Thr180, Tyr182) Antibody (MA5-33089) in IHC (P)
Immunohistochemistry analysis of formalin fixed and paraffin embedded human breast cancer tissue sections usingPhospho-p38 MAPK beta (Thr180, Tyr182) Recombinant Monoclonal antibody (Product # MA5-33089) at a dilution of 1:1,000.
Product Details
MA5-33089
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RM243
Immunogen
A phospho-peptide corresponding to human Phosphop38 MAPK (Thr180/Tyr182).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Protein A
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2810181
Product Specific Information
Specificity: reacts to p38 MAPK only when dual phosphorylation at Thr180 and Tyr182 is observed. There is no cross-reactivity with p38 MAPK without dual phosphorylation at Thr180 and Tyr182.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
MAPK11 (p38 beta) is a serine/threonine kinase which is involved in a variety of cellular processes, and is activated by proinflammatory cytokines and environmental stress. Mitogen-activated protein kinase 11. The protein encoded by p38 MAPK beta is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase 11; MAP kinase p38 beta; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; OTTHUMP00000196655; p38-2; SAPK2b; Stress-activated protein kinase 2b; stress-activated protein kinase-2; stress-activated protein kinase-2b
Gene Aliases: MAPK11; p38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B
UniProt ID: (Human) Q15759
Entrez Gene ID: (Human) 5600
MAPK cascade
activation of MAPK activity
transcription, DNA-templated
response to stress
signal transduction
Ras protein signal transduction
positive regulation of gene expression
intracellular signal transduction
positive regulation of erythrocyte differentiation
vascular endothelial growth factor receptor signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
positive regulation of muscle cell differentiation
negative regulation of cardiac muscle cell proliferation
cellular response to virus
regulation of signal transduction by p53 class mediator
positive regulation of interleukin-12 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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