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Invitrogen
Phospho-p70 S6 Kinase (Ser398) Polyclonal Antibody
FIGURE: 1 / 1
Phospho-p70 S6 Kinase (Ser398) Antibody (PA5-95681) in WB
Western blot of p70 S6 Kinase in Drosophila S2 cell lysate showing specific labeling of a band at ~70 kDa corresponding to Phospho-p70 S6 Kinase (Ser398) polyclonal antibody (Product # PA5-95681) in the first lane (-). Immunolabeling is blocked by pre-adsorption with the phosphopeptide used as antigen in the second lane (+), but not by the corresponding non-phosphopeptide (not shown).
Product Details
PA5-95681
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr398 conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen Affinity Chromatography
Storage buffer
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 150mM NaCl
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807483
Product Specific Information
Antigen Affinity Purified from Pooled Serum
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG10539-PA; CG10539-PB; Dp70s6k; dS6 kinase; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase; p70 S6 kinase; p70 S6 kinase 1; p70S6 kinase; p70S6K kinase; p70S6K-alpha; p80-S6K 1; p85 p85S6K; protein kinase-like 64F; ribosomal S6 protein kinase; RPS6-p70-protein kinase; S6 kinase; S6-kinase; S6K kinase; S6k-PA; S6k-PB; S6kinase
Gene Aliases: 10539; 7-10; 7084; CG10539; d-S6K; Dmel\CG10539; Dmel_CG10539; Dp70[s6k]; Dp70S6k; dps6k; DS6K; dS6K1; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70[S6 kinase]; p70[S6K]; p70[S6kinase]; p70S6K; Pk64F; Pk?6; S6 K; S6K; S6K1; s6k11; S6k|S6K
Entrez Gene ID: (Fruit fly) 38654
protein phosphorylation
response to oxidative stress
insulin receptor signaling pathway
determination of adult lifespan
positive regulation of autophagy
positive regulation of cell growth
larval feeding behavior
cellular response to insulin stimulus
multicellular organism growth
intracellular signal transduction
female germ-line stem cell population maintenance
TORC1 signaling
positive regulation of cell size
vascular endothelial growth factor receptor signaling pathway
dendrite morphogenesis
synaptic growth at neuromuscular junction
lipid homeostasis
cellular response to amino acid stimulus
positive regulation of axon guidance
regulation of terminal button organization
regulation of response to drug
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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