Proteintech

Placental Growth Factor Polyclonal Antibody

Placental Growth Factor Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Placental Growth Factor Antibody (10642-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using (Product # 10642-1-AP) (Placental Growth Factor antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Placental Growth Factor Antibody in Western Blot (WB)

Placental Growth Factor Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10642-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:800

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 9 publications 9 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Placental Growth Factor Fusion Protein Ag0969 (1-170 aa encoded by BC007789)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPVMRLFPC FLQLLAGLAL PAVPPQQWAL SAGNGSSEVE VVPFQEVWGR SYCRALERLV DVVSEYPSEV EHMFSPSCVS LLRCTGCCGD ENLHCVPVET ANVTMQLLKI RSGDRPSYVE LTFSQHVRCE CRPLREKMKP ERRRPKGRGK RRREKQRPTD CHLCGDAVPR R (1-170 aa encoded by BC007789)

Target Information

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family. PlGF is a pleiotropic factor affects different cell types and regulates various biological responses. The activity of vascular endothelial growth factor (VEGF), which is the most potent of all angiogenic mediators, is partly modulated by PlGF. It plays a major role in vasculogenesis and angiogenesis in human placenta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

HIF-1α inhibitor YC-1 suppresses triple-negative breast cancer growth and angiogenesis by targeting PlGF/VEGFR1-induced macrophage polarization.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Li Y,Zhang MZ,Zhang SJ,Sun X,Zhou C,Li J,Liu J,Feng J,Lu SY,Pei-Jun L,Wang JC

Mon May 01 00:00:00 EDT 2023

HIF-1α inhibitor YC-1 suppresses triple-negative breast cancer growth and angiogenesis by targeting PlGF/VEGFR1-induced macrophage polarization.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Li Y,Zhang MZ,Zhang SJ,Sun X,Zhou C,Li J,Liu J,Feng J,Lu SY,Pei-Jun L,Wang JC

Mon May 01 00:00:00 EDT 2023

Ulinastatin ameliorates preeclampsia induced by N(gamma)-nitro-l-arginine methyl ester in a rat model via inhibition of the systemic and placental inflammatory response.

Journal of hypertension

Yu Z,Liu Y,Zhang Y,Cui J,Dong Y,Zhang L,Liu P,Hao Y,Xu Y,Wang J

Sun Jan 01 00:00:00 EST 2023

Alzheimer's Amyloid β Peptide Induces Angiogenesis in an Alzheimer's Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions.

International journal of molecular sciences

Sheikh AM,Yano S,Tabassum S,Mitaki S,Michikawa M,Nagai A

Fri Feb 24 00:00:00 EST 2023

Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.

Diabetes, obesity & metabolism

Jiang Y,Chen A,Kline D,Liu Q,Ma J,Wang Y,Zhang T,Qian J,Nelson L,Prasadan K,Hu B,Gittes GK,Xiao X

Thu Sep 01 00:00:00 EDT 2022

Development and Validation of Novel Prognostic Models for Immune-Related Genes in Osteosarcoma.

Frontiers in molecular biosciences

Li J,Su L,Xiao X,Wu F,Du G,Guo X,Kong F,Yao J,Zhu H

Sat Jul 16 00:00:00 EDT 2022

Analysis of the potential association between ferroptosis and immune in hepatocellular carcinoma and their relationship with prognosis.

Frontiers in oncology

Wen K,Yang F,Hu L,Shi J,Mui S,Wang W,Liao H,Li H,Xiao Z,Yan Y

Tue Feb 14 00:00:00 EST 2023

MAPK-RAP1A Signaling Enriched in Hepatocellular Carcinoma Is Associated With Favorable Tumor-Infiltrating Immune Cells and Clinical Prognosis.

Frontiers in oncology

Li H,Han G,Li X,Li B,Wu B,Jin H,Wu L,Wang W

Sun Apr 24 00:00:00 EDT 2022

Prolactin (PRL), placenta growth factor (PIGF) and nerve growth factor receptor (NGFR) as biomarkers for early diagnosis and prognosis in patients with esophageal squamous cell carcinoma (ESCC).

Translational cancer research

Ai X,Zhu X,Zuo J

Sat Feb 01 00:00:00 EST 2020

Occurrence of Fibrotic Tumor Vessels in Grade I Meningiomas Is Strongly Associated with Vessel Density, Expression of VEGF, PlGF, IGFBP-3 and Tumor Recurrence.

Cancers

Hess K,Spille DC,Adeli A,Sporns PB,Zitta K,Hummitzsch L,Pfarr J,Stummer W,Brokinkel B,Berndt R,Albrecht M

Wed Oct 21 00:00:00 EDT 2020

"Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines.

Reproductive toxicology (Elmsford, N.Y.)

Drwal E,Rak A,Tworzydło W,Gregoraszczuk EŁ

Sat Aug 01 00:00:00 EDT 2020

"Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines.

Reproductive toxicology (Elmsford, N.Y.)

Drwal E,Rak A,Tworzydło W,Gregoraszczuk EŁ

Sat Aug 01 00:00:00 EDT 2020

The role and mechanism of asymmetric dimethylarginine in fetal growth restriction via interference with endothelial function and angiogenesis.

Journal of assisted reproduction and genetics

Dai Y,Zhang J,Liu R,Xu N,Yan SB,Chen Y,Li TH

Fri May 01 00:00:00 EDT 2020

Identification of a novel cancer stem cell subpopulation that promotes progression of human fatal renal cell carcinoma by single-cell RNA-seq analysis.

International journal of biological sciences

Pan XW,Zhang H,Xu D,Chen JX,Chen WJ,Gan SS,Qu FJ,Chu CM,Cao JW,Fan YH,Song X,Ye JQ,Zhou W,Cui XG

Fri Nov 12 00:00:00 EST 2021

Identification of a novel cancer stem cell subpopulation that promotes progression of human fatal renal cell carcinoma by single-cell RNA-seq analysis.

International journal of biological sciences

Pan XW,Zhang H,Xu D,Chen JX,Chen WJ,Gan SS,Qu FJ,Chu CM,Cao JW,Fan YH,Song X,Ye JQ,Zhou W,Cui XG

Fri Nov 12 00:00:00 EST 2021

MiR-124-3p promotes trophoblast cell HTR-8/SVneo pyroptosis by targeting placental growth factor.

Placenta

Tao J,Xia LZ,Liang L,Chen Y,Wei D,Meng J,Wu S,Wang Z

Sun Nov 01 00:00:00 EDT 2020

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 EST 2019

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 EST 2019

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 EST 2019

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 EST 2019

Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.

Biomaterials

Song Y,Tang C,Yin C

Sat Dec 01 00:00:00 EST 2018

Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.

Biomaterials

Song Y,Tang C,Yin C

Sat Dec 01 00:00:00 EST 2018

The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer.

Cancer science

Li H,Jin Y,Hu Y,Jiang L,Liu F,Zhang Y,Hao Y,Chen S,Wu X,Liu Y

Tue May 01 00:00:00 EDT 2018

The PLGF/c-MYC/miR-19a axis promotes metastasis and stemness in gallbladder cancer.

Cancer science

Li H,Jin Y,Hu Y,Jiang L,Liu F,Zhang Y,Hao Y,Chen S,Wu X,Liu Y

Tue May 01 00:00:00 EDT 2018

Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia.

Journal of cellular and molecular medicine

Ma Y,Kong LR,Ge Q,Lu YY,Hong MN,Zhang Y,Ruan CC,Gao PJ

Thu Feb 01 00:00:00 EST 2018

Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia.

Journal of cellular and molecular medicine

Ma Y,Kong LR,Ge Q,Lu YY,Hong MN,Zhang Y,Ruan CC,Gao PJ

Thu Feb 01 00:00:00 EST 2018

Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia.

Journal of cellular and molecular medicine

Ma Y,Kong LR,Ge Q,Lu YY,Hong MN,Zhang Y,Ruan CC,Gao PJ

Thu Feb 01 00:00:00 EST 2018

Complement 5a-mediated trophoblasts dysfunction is involved in the development of pre-eclampsia.

Journal of cellular and molecular medicine

Ma Y,Kong LR,Ge Q,Lu YY,Hong MN,Zhang Y,Ruan CC,Gao PJ

Thu Feb 01 00:00:00 EST 2018

Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction.

Reproduction (Cambridge, England)

Wu WB,Xu YY,Cheng WW,Yuan B,Zhao JR,Wang YL,Zhang HJ

Fri Sep 01 00:00:00 EDT 2017

Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction.

Reproduction (Cambridge, England)

Wu WB,Xu YY,Cheng WW,Yuan B,Zhao JR,Wang YL,Zhang HJ

Fri Sep 01 00:00:00 EDT 2017

Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia.

Hypertension in pregnancy

Ehrlich L,Hoeller A,Golic M,Herse F,Perschel FH,Henrich W,Dechend R,Huppertz B,Verlohren S

Mon May 01 00:00:00 EDT 2017

Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia.

Hypertension in pregnancy

Ehrlich L,Hoeller A,Golic M,Herse F,Perschel FH,Henrich W,Dechend R,Huppertz B,Verlohren S

Mon May 01 00:00:00 EDT 2017

Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection.

Brain : a journal of neurology

Hedlund E,Karlsson M,Osborn T,Ludwig W,Isacson O

Sun Aug 01 00:00:00 EDT 2010

Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection.

Brain : a journal of neurology

Hedlund E,Karlsson M,Osborn T,Ludwig W,Isacson O

Sun Aug 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: Placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein; PlGF; PlGF 1; SHGC

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Gene Aliases: AI854365; D12S1900; PGF; PGFL; PIGF; PLGF; PlGF-2; SHGC-10760

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UniProt ID: (Human) P49763, (Mouse) P49764

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Entrez Gene ID: (Human) 5228, (Mouse) 18654

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Function(s)

protein binding growth factor activity heparin binding protein homodimerization activity protein heterodimerization activity growth factor

Process(es)

branching involved in ureteric bud morphogenesis response to hypoxia positive regulation of endothelial cell proliferation sprouting angiogenesis signal transduction cell-cell signaling female pregnancy positive regulation of cell proliferation cell differentiation organ regeneration cellular response to hormone stimulus response to drug positive regulation of angiogenesis vascular endothelial growth factor receptor signaling pathway positive regulation of cell division regulation of morphogenesis of a branching structure angiogenesis multicellular organism development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Placental Growth Factor Polyclonal Antibody

Placental Growth Factor Antibody (10642-1-AP) in IHC (P)

Product Details

10642-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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