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Invitrogen
Podocin Monoclonal Antibody (C3)
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
Podocin Antibody (MA5-43645) in WB
Western blot analysis of Podocin in Lane 1: human placenta lysate; Lane 2: 293T cell lysate; Lane 3: porcine Kidney lysate; Lane 4: rat Kidney lysate. Samples were incubated in monoclonal Podocin antibody (Product # MA5-43645) using a dilution of 2 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 0.2 µg/mL.
Product Details
MA5-43645
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
C3
Immunogen
Met222-Pro372 (Accession Q9NP85), with N-terminal His Tag
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2912577
Target Information
The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant (podocin); NPHS2 podocin; Podocin
Gene Aliases: AI790225; NPHS2; PDCN; podocin; SRN1
UniProt ID: (Human) Q9NP85, (Mouse) Q91X05, (Rat) Q8K4G9
Entrez Gene ID: (Human) 7827, (Mouse) 170484, (Rat) 170672
Performance Guarantee
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