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FIGURE: 1 / 1
Podoplanin Antibody (BS-10673R) in WB
Lane 1:Human U-2OS cell lysates; Lane 2: Human U-87MG cell lysates; Lane 3: Human 293T cell lysates; Lane 4: Human MG63 cell lysates; Lane 5: Human U251 cell lysates probed with Podoplanin Polyclonal Antibody, Unconjugated (bs-10673R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-10673R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from Rat Podoplanin (31-130).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aggrus; CTA-520D8.1; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; Glycoprotein 36; glycoprotein 38; glycoprotein, 36-KD; Gp36; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTTHUMP00000009640; OTTHUMP00000044504; PA2.26 antigen; PDPN; Podoplanin; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RP23-348F1.2; RTI140; T1-alpha; T1A; Type I cell 40 kDa protein
Gene Aliases: AGGRUS; E11; GP36; Gp38; GP40; HT1A-1; OTS-8; OTS8; PA2.26; PDPN; PSEC0003; PSEC0025; RTI40; T1-alpha; T1A; T1A-2; T1A2; TI1A
UniProt ID: (Human) Q86YL7, (Rat) Q64294
Entrez Gene ID: (Human) 10630, (Rat) 54320
cell morphogenesis
lymphangiogenesis
prostaglandin metabolic process
water transport
amino acid transport
signal transduction
cell proliferation
regulation of cell shape
folic acid transport
single organismal cell-cell adhesion
platelet activation
lung development
lung alveolus development
cell motility
positive regulation of cellular component movement
regulation of G1/S transition of mitotic cell cycle
inflammatory response
cell adhesion
nervous system development
positive regulation of platelet activation
positive regulation of cell migration
tube morphogenesis
response to hyperoxia
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