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Podoplanin Antibody (MA5-18054) in IHC (F)
Immunofluorescent analysis of Podoplanin in frozen sections of mouse kidney cells using a Podoplanin monoclonal antibody (Product # MA5-18054) at a dilution ranging from 0.1-10 µg/mL. Detection was performed using a secondary antibody at a dilution of 1:1000.
Product Details
MA5-18054
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse
Host/Isotype
Syrian hamster
/ IgG
Class
Monoclonal
Type
Antibody
Clone
8.1.1
Immunogen
Thymic epithelial mouse cells
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2539437
Product Specific Information
This target has a predicted molecular weight of 25 kDa.
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aggrus; CTA-520D8.1; E11; Glycoprotein 38; Gp38; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26 antigen; Podoplanin; RP23-348F1.2; Transmembrane glycoprotein E11
Gene Aliases: Gp38; OTS-8; Ots8; Pdpn; RANDAM-2; T1-alpha; T1a; T1alpha
UniProt ID: (Mouse) Q62011
Entrez Gene ID: (Mouse) 14726
cell morphogenesis
lymphangiogenesis
prostaglandin metabolic process
water transport
amino acid transport
movement of cell or subcellular component
cell adhesion
signal transduction
multicellular organism development
cell proliferation
regulation of cell shape
positive regulation of platelet activation
folic acid transport
single organismal cell-cell adhesion
lung development
positive regulation of cell migration
tube morphogenesis
lung alveolus development
positive regulation of cellular component movement
visceral serous pericardium development
regulation of G1/S transition of mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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