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Additional Information: This antibody is expected to recognize both reported isoforms (NP_001009944.1 and NP_000287.2).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Autosomal dominant polycystic kidney disease 1 protein; PC1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease-associated protein; polycystin 1; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1
Gene Aliases: PBP; Pc-1; PKD1; TRPP1
UniProt ID: (Human) P98161
Entrez Gene ID: (Human) 5310
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