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PrP Antibody (PA1-41373) in WB
Western blot analysis of PrP in recombinant fusion protein. Samples were incubated in PrP polyclonal antibody (Product # PA1-41373 using a dilution of 5 µg/mL. (A) recombinant fusion protein containing amino acids 162-170 and (B) fusion partner without these amino acids.
Product Details
PA1-41373
Product Specifications
Species Reactivity
Avian,
Bovine,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues 162-170 of BSE.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS with 0.2% gelatin
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_1086794
Product Specific Information
Suggested positive control: recombinant fusion protein.
Target Information
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alternative prion protein; AltPrP; BSE; CD230; Major prion protein; Major scrapie-associated fibril protein 1; MGC26679; PK resistant core; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; PrP; PrPc; TSE
Gene Aliases: AltPrP; prn; PRNP; PRP; PRPC; SIP
UniProt ID: (Bovine) F7VJQ2, (Sheep) P23907
Entrez Gene ID: (Bovine) 281427, (Sheep) 493887
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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