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Presenilin-1 Polyclonal Antibody

Presenilin-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Presenilin-1 Antibody (16163-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using (Product # 16163-1-AP) (Presenilin-1-Specific antibody) at dilution of 1:1,000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Presenilin-1 Antibody in Western Blot (WB)

Presenilin-1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16163-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to isoform 1 (53 kDa), isoform 2 (52 kDa), isoform 4 (21 kDa), isoform 7 (49 kDa) of this protein.

Target Information

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 mice.

CNS neuroscience & therapeutics

Luo B,Chen J,Zhou GF,Xie XY,Tang J,Wen QX,Song L,Xie SQ,Long Y,Chen GJ,Hu XT

Mon May 01 00:00:00 EDT 2023

Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice.

Journal of neuroinflammation

Li Q,Peng J,Luo Y,Zhou J,Li T,Cao L,Peng S,Zuo Z,Wang Z

Tue Jun 14 00:00:00 EDT 2022

The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.

Cell reports

Gerosa L,Mazzoleni S,Rusconi F,Longaretti A,Lewerissa E,Pelucchi S,Murru L,Giannelli SG,Broccoli V,Marcello E,Kasri NN,Battaglioli E,Passafaro M,Bassani S

Tue May 24 00:00:00 EDT 2022

Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.

Neuroscience letters

Inoue Y,Masuda T,Misumi Y,Ando Y,Ueda M

Sat Sep 25 00:00:00 EDT 2021

BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease.

Cell death discovery

Zhang X,Li J,Ma L,Xu H,Cao Y,Liang W,Ma J,Wang ZP,Li Y

Mon Mar 15 00:00:00 EDT 2021

Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.

Cell biology international

Wang X,Yang G

Thu Apr 01 00:00:00 EDT 2021

Presenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma.

Cell communication and signaling : CCS

Yang W,Wu PF,Ma JX,Liao MJ,Xu LS,Xu MH,Yi L

Tue Feb 11 00:00:00 EST 2020

Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Wei H,Zhang HL,Wang XC,Xie JZ,An DD,Wan L,Wang JZ,Zeng Y,Shu XJ,Westermarck J,Lu YM,Ohlmeyer M,Liu R

Wed Jul 01 00:00:00 EDT 2020

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Neuroscience bulletin

Zhang Y,Xie JZ,Xu XY,Hu J,Xu T,Jin S,Yang SJ,Wang JZ

Thu Aug 01 00:00:00 EDT 2019

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Neuroscience bulletin

Zhang Y,Xie JZ,Xu XY,Hu J,Xu T,Jin S,Yang SJ,Wang JZ

Thu Aug 01 00:00:00 EDT 2019

MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.

Brain : a journal of neurology

Zhu BL,Long Y,Luo W,Yan Z,Lai YJ,Zhao LG,Zhou WH,Wang YJ,Shen LL,Liu L,Deng XJ,Wang XF,Sun F,Chen GJ

Tue Jan 01 00:00:00 EST 2019

Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.

Molecular neurobiology

Inoue Y,Ueda M,Masuda T,Misumi Y,Yamashita T,Ando Y

Sun Dec 01 00:00:00 EST 2019

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Cell reports

Shentu YP,Huo Y,Feng XL,Gilbert J,Zhang Q,Liuyang ZY,Wang XL,Wang G,Zhou H,Wang XC,Wang JZ,Lu YM,Westermarck J,Man HY,Liu R

Tue Jul 17 00:00:00 EDT 2018

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Cell reports

Shentu YP,Huo Y,Feng XL,Gilbert J,Zhang Q,Liuyang ZY,Wang XL,Wang G,Zhou H,Wang XC,Wang JZ,Lu YM,Westermarck J,Man HY,Liu R

Tue Jul 17 00:00:00 EDT 2018

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Cell reports

Shentu YP,Huo Y,Feng XL,Gilbert J,Zhang Q,Liuyang ZY,Wang XL,Wang G,Zhou H,Wang XC,Wang JZ,Lu YM,Westermarck J,Man HY,Liu R

Tue Jul 17 00:00:00 EDT 2018

Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells.

Oncotarget

Mushtaq M,Pangigadde PN,Darekar S,Dissen E,Kashuba E

Tue Sep 12 00:00:00 EDT 2017

Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.

The Journal of nutritional biochemistry

Cai D,Yuan M,Jia Y,Liu H,Hu Y,Zhao R

Tue Dec 01 00:00:00 EST 2015

Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.

The Journal of nutritional biochemistry

Cai D,Yuan M,Jia Y,Liu H,Hu Y,Zhao R

Tue Dec 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: Alzheimer Disease 3; Minilin; Presenilin-1; presenilin1; Protein S182; PS-1; S182 protein; Senilin 1

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Gene Aliases: AD3; Ad3h; FAD; PS-1; PS1; PSEN1; PSNL1; S182

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UniProt ID: (Human) P49768, (Rat) P97887

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Entrez Gene ID: (Human) 5663, (Rat) 29192, (Mouse) 19164

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Function(s)

endopeptidase activity aspartic-type endopeptidase activity calcium channel activity protein binding beta-catenin binding PDZ domain binding cadherin binding peptidase activity hydrolase activity aspartic endopeptidase activity, intramembrane cleaving aspartic protease

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Presenilin-1 Polyclonal Antibody

Presenilin-1 Antibody (16163-1-AP) in IHC (P)

Product Details

16163-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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