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Product Details
60092-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4D3G5
Immunogen
Prohibitin Fusion Protein Ag1240 (1-272 aa encoded by BC013401)
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAKVFESI GKFGLALAVA GGVVNSALYN VDAGHRAVIF DRFRGVQDIV VGEGTHFLIP WVQKPIIFDC RSRPRNVPVI TGSKDLQNVN ITLRILFRPV ASQLPRIFTS IGEDYDERVL PSITTEILKS VVARFDAGEL ITQRELVSRQ VSDDLTERAA TFGLILDDVS LTHLTFGKEF TEAVEAKQVA QQEAERARFV VEKAEQQKKA AIISAEGDSK AAELIANSLA TAGDGLIELR KLEAAEDIAY QLSRSRNITY LPAGQSVLLQ LPQ (1-272 aa encoded by BC013401)
Target Information
Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; prohibitin; Prohibitin 1
Gene Aliases: HEL-215; HEL-S-54e; PHB; PHB1
UniProt ID: (Human) P35232, (Rat) P67779
Entrez Gene ID: (Human) 5245, (Pig) 100524707, (Rat) 25344
RNA polymerase II transcription factor activity, sequence-specific DNA binding
complement component C3a binding
complement component C3b binding
protein binding
protein C-terminus binding
enzyme binding
proteinase activated receptor binding
histone deacetylase binding
transcription regulatory region DNA binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
regulation of transcription, DNA-templated
mitochondrion organization
signal transduction
negative regulation of cell proliferation
negative regulation of transcription by competitive promoter binding
histone deacetylation
negative regulation of cell growth
negative regulation of protein catabolic process
regulation of apoptotic process
positive regulation of G-protein coupled receptor protein signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of complement activation
protein stabilization
progesterone receptor signaling pathway
negative regulation of androgen receptor signaling pathway
negative regulation of ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to interleukin-6
DNA biosynthetic process
negative regulation of glucocorticoid receptor signaling pathway
ovarian follicle development
ovarian follicle atresia
transcription from RNA polymerase II promoter
organ regeneration
response to cytokine
response to immobilization stress
response to drug
negative regulation of apoptotic process
response to peptide hormone
response to ethanol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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