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Bioss
ProsTaglandin E Receptor EP4 Polyclonal Antibody, Alexa Fluor™ 647
Product Details
BS-24918R-A647
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from mouse EP4
Conjugate
Excitation/Emission Max
650/671 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EP1; MGC126583; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor
Gene Aliases: EP4; Ptger4; Ptgerep4
UniProt ID: (Mouse) P32240
Entrez Gene ID: (Mouse) 19219
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
JNK cascade
intestine smooth muscle contraction
positive regulation of smooth muscle cell migration
regulation of ossification
positive regulation of cAMP biosynthetic process
response to lipopolysaccharide
positive regulation of interleukin-8 production
negative regulation of integrin activation
positive regulation of urine volume
positive regulation of renal sodium excretion
T-helper cell differentiation
positive regulation of bone resorption
negative regulation of cytokine secretion
positive regulation of cytokine secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of oxidoreductase activity
regulation of stress fiber assembly
bone development
positive regulation of mucus secretion
ERK1 and ERK2 cascade
ductus arteriosus closure
positive regulation of hyaluronan biosynthetic process
positive regulation of ovarian follicle development
positive regulation of antral ovarian follicle growth
positive regulation of neutrophil extravasation
negative regulation of eosinophil extravasation
negative regulation of peroxidase activity
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