Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
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Immunogen sequence: MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FPC; multiple intestinal neoplasia; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
Gene Aliases: AI047805; APC; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46; RATAPC
UniProt ID: (Human) P25054, (Rat) P70478
Entrez Gene ID: (Human) 324, (Mouse) 11789, (Rat) 24205
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