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Invitrogen
Prothrombin Fragment 1/2 Monoclonal Antibody (D3)
FIGURE: 1 / 2
Prothrombin Fragment 1/2 Antibody (MA5-50945) in IHC (P)
Immunohistochemistry (Paraffin) analysis of Prothrombin Fragment 1/2 in Human Liver Tissue. Samples were incubated in Prothrombin Fragment 1/2 monoclonal antibody (Product # MA5-50945) using a dilution of 10 µg/mL followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB staining.
Product Details
MA5-50945
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Mouse
/ IgG2a, lambda
Class
Monoclonal
Type
Antibody
Clone
D3
Immunogen
Recombinant Human F1+2 protein, Ala44-Arg327 (Accession #P00734)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% Proclin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_3093444
Target Information
Prothrombin Fragment 1/2 is a protein fragment that is produced by the cleavage of prothrombin, a blood clotting protein. It is a small peptide consisting of the first half of the prothrombin molecule and is involved in the formation of blood clots. Prothrombin Fragment 1/2 is used as a biomarker for the diagnosis and monitoring of various blood clotting disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; Prothrombin fragment 1+2; prothrombin fragment 1.2; Prothrombin fragment F1+2; prothrombin fragment F1.2; serine protease; thrombin
Gene Aliases: F2; PT; RPRGL2; THPH1
UniProt ID: (Pig) Q19AZ8, (Human) P00734
Entrez Gene ID: (Pig) 100144442, (Human) 2147
proteolysis
acute-phase response
positive regulation of protein phosphorylation
signal peptide processing
ER to Golgi vesicle-mediated transport
cell surface receptor signaling pathway
multicellular organism development
blood coagulation
blood coagulation, intrinsic pathway
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
peptidyl-glutamic acid carboxylation
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
fibrinolysis
cellular protein metabolic process
negative regulation of proteolysis
negative regulation of astrocyte differentiation
leukocyte migration
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
negative regulation of fibrinolysis
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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