Proteintech

RAB11A Polyclonal Antibody

RAB11A Antibody in Immunocytochemistry (ICC/IF)

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RAB11A Antibody (20229-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HeLa cells using 20229-1-AP (RAB11A-Specific antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

RAB11A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RAB11A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

20229-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 8 publications 8 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Dog, Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific to RAB11A, and has no cross reaction to RAB11B.

Target Information

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA.

Neurochemistry international

Liu M,Li X,Wang J,Ji Y,Gu J,Wei Y,Peng L,Tian C,Lv P,Wang P,Liu X,Li W

Fri Sep 01 00:00:00 EDT 2023

Identification and validation of Rab11a in Rat orofacial inflammatory pain model induced by CFA.

Neurochemistry international

Liu M,Li X,Wang J,Ji Y,Gu J,Wei Y,Peng L,Tian C,Lv P,Wang P,Liu X,Li W

Fri Sep 01 00:00:00 EDT 2023

Metabotropic glutamate receptor 5 upregulation of γ-aminobutyric acid transporter 3 expression ameliorates cognitive impairment after traumatic brain injury in mice.

Brain research bulletin

Xu P,Huang X,Niu W,Yu D,Zhou M,Wang H

Wed Jun 01 00:00:00 EDT 2022

Metabotropic glutamate receptor 5 upregulation of γ-aminobutyric acid transporter 3 expression ameliorates cognitive impairment after traumatic brain injury in mice.

Brain research bulletin

Xu P,Huang X,Niu W,Yu D,Zhou M,Wang H

Wed Jun 01 00:00:00 EDT 2022

Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.

EMBO reports

Chen Y,Wu X,Zhang J,Pan G,Wang X,Guo X,Wang J,Cui X,Gao H,Cheng M,Yang J,Zhang C,Jiang F

Thu Feb 03 00:00:00 EST 2022

Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.

Cellular and molecular gastroenterology and hepatology

Mareninova OA,Dillon DL,Wightman CJM,Yakubov I,Takahashi T,Gaisano HY,Munson K,Ohmuraya M,Dawson D,Gukovsky I,Gukovskaya AS

Mon Apr 04 00:00:00 EDT 2022

Rab11a mediates cell-cell spread and reassortment of influenza A virus genomes via tunneling nanotubes.

PLoS pathogens

Ganti K,Han J,Manicassamy B,Lowen AC

Wed Sep 01 00:00:00 EDT 2021

TBC1 domain family member 23 interacts with Ras-related protein Rab-11A to promote poor prognosis of non-small-cell lung cancer via β1-integrin.

Journal of cellular and molecular medicine

Zhang Y,Su H,Wudu M,Ren H,Xu Y,Zhang Q,Jiang J,Wang Q,Jiang X,Zhang B,Liu Z,Zou Z,Qiu X

Wed Sep 01 00:00:00 EDT 2021

TBC1 domain family member 23 interacts with Ras-related protein Rab-11A to promote poor prognosis of non-small-cell lung cancer via β1-integrin.

Journal of cellular and molecular medicine

Zhang Y,Su H,Wudu M,Ren H,Xu Y,Zhang Q,Jiang J,Wang Q,Jiang X,Zhang B,Liu Z,Zou Z,Qiu X

Wed Sep 01 00:00:00 EDT 2021

Increased potency of recombinant VWF D'D3 albumin fusion proteins engineered for enhanced affinity for coagulation factor VIII.

Journal of thrombosis and haemostasis : JTH

Chia J,Pestel S,Glauser I,Emmrich K,Hardy MP,Mischnik M,Raquet E,Tomasetig V,Claar P,Zalewski A,Bass GT,Turnbull V,Chen CG,Wilson MJ,Panousis C,Weimer T,Andrews A,Verhagen AM,Dower SK

Mon Nov 01 00:00:00 EDT 2021

DIAPH1 regulates ciliogenesis and trafficking in primary cilia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Palander O,Trimble WS

Tue Dec 01 00:00:00 EST 2020

An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice.

British journal of pharmacology

Lu W,Tian H,Qian P,Li Y,Wang Y,Ge Y,Sai W,Gao X,Yao W

Sat Aug 01 00:00:00 EDT 2020

Visualizing Coronavirus Entry into Cells.

Methods in molecular biology (Clifton, N.J.)

Milewska A,Owczarek K,Szczepanski A,Pyrc K

Fri Sep 11 00:00:00 EDT 2020

Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Essandoh K,Deng S,Wang X,Jiang M,Mu X,Peng J,Li Y,Peng T,Wagner KU,Rubinstein J,Fan GC

Sat Jun 01 00:00:00 EDT 2019

Upregulation and hypomethylation of lncRNA AFAP1‑AS1 predicts a poor prognosis and promotes the migration and invasion of cervical cancer.

Oncology reports

Bo H,Fan L,Gong Z,Liu Z,Shi L,Guo C,Li X,Liao Q,Zhang W,Zhou M,Xiang B,Li X,Li G,Xiong W,Zeng Z,Cao K,Zhang S,Xiong F

Mon Apr 01 00:00:00 EDT 2019

BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia.

The Journal of cell biology

Monis WJ,Faundez V,Pazour GJ

Mon Jul 03 00:00:00 EDT 2017

BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia.

The Journal of cell biology

Monis WJ,Faundez V,Pazour GJ

Mon Jul 03 00:00:00 EDT 2017

Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Gomi H,Osawa H,Uno R,Yasui T,Hosaka M,Torii S,Tsukise A

Wed Nov 01 00:00:00 EDT 2017

Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Gomi H,Osawa H,Uno R,Yasui T,Hosaka M,Torii S,Tsukise A

Wed Nov 01 00:00:00 EDT 2017

Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Gomi H,Osawa H,Uno R,Yasui T,Hosaka M,Torii S,Tsukise A

Wed Nov 01 00:00:00 EDT 2017

Canine Salivary Glands: Analysis of Rab and SNARE Protein Expression and SNARE Complex Formation With Diverse Tissue Properties.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Gomi H,Osawa H,Uno R,Yasui T,Hosaka M,Torii S,Tsukise A

Wed Nov 01 00:00:00 EDT 2017

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.

Proceedings of the National Academy of Sciences of the United States of America

Humbert MC,Weihbrecht K,Searby CC,Li Y,Pope RM,Sheffield VC,Seo S

Tue Nov 27 00:00:00 EST 2012

Bioinformatics

Protein Aliases: 24KG; RAB 11A, member oncogene family; Rab-11; Ras-related protein Rab-11A; YL8

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Gene Aliases: RAB11; RAB11A; YL8

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UniProt ID: (Human) P62491, (Rat) P62494, (Mouse) P62492

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Entrez Gene ID: (Human) 8766, (Rat) 81830, (Mouse) 53869

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Function(s)

GTPase activity protein binding GTP binding microtubule binding syntaxin binding myosin V binding GDP binding nucleotide binding

Process(es)

intracellular protein transport exocytosis mitotic metaphase plate congression metabolic process positive regulation of epithelial cell migration regulation of multivesicular body size positive regulation of G2/M transition of mitotic cell cycle vesicle-mediated transport astral microtubule organization neuron projection development melanosome transport Rab protein signal transduction multivesicular body assembly positive regulation of axon extension regulation of long-term neuronal synaptic plasticity regulation of protein transport establishment of vesicle localization regulation of vesicle-mediated transport establishment of protein localization to organelle protein localization to plasma membrane establishment of protein localization to membrane mitotic spindle assembly exosomal secretion cytokinesis renal water homeostasis small GTPase mediated signal transduction protein transport plasma membrane to endosome transport transport cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAB11A Polyclonal Antibody

RAB11A Antibody (20229-1-AP) in ICC/IF

Product Details

20229-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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