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RAB11A Antibody (MA5-37686) in IHC (P)
Immunohistochemistry (Paraffin) analysis of RAB11A in human brain sections using the RAB11A Monoclonal Antibody (Product # MA5-37686) at a dilution of 1:25. Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted bioti... View More
Product Details
MA5-37686
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1565CT164.36.80
Immunogen
purified recombinant protein of human RAB11A
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897610
Target Information
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24KG; RAB 11A, member oncogene family; Rab-11; Ras-related protein Rab-11A; YL8
Gene Aliases: RAB11; RAB11A; YL8
UniProt ID: (Human) P62491, (Rat) P62494, (Mouse) P62492
Entrez Gene ID: (Human) 8766, (Rat) 81830, (Mouse) 53869
intracellular protein transport
exocytosis
mitotic metaphase plate congression
metabolic process
positive regulation of epithelial cell migration
regulation of multivesicular body size
positive regulation of G2/M transition of mitotic cell cycle
vesicle-mediated transport
astral microtubule organization
neuron projection development
melanosome transport
Rab protein signal transduction
multivesicular body assembly
positive regulation of axon extension
regulation of long-term neuronal synaptic plasticity
regulation of protein transport
establishment of vesicle localization
regulation of vesicle-mediated transport
establishment of protein localization to organelle
protein localization to plasma membrane
establishment of protein localization to membrane
mitotic spindle assembly
exosomal secretion
cytokinesis
renal water homeostasis
small GTPase mediated signal transduction
protein transport
plasma membrane to endosome transport
transport
cell cycle
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