Proteintech

RAB11A/B Polyclonal Antibody

RAB11A/B Antibody in Immunocytochemistry (ICC/IF)

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RAB11A/B Antibody (15903-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using RAB11A/B antibody (Product # 15903-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

RAB11A/B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RAB11A/B Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15903-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 11 publications 11 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Dog, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RAB11A/B Fusion Protein Ag8742 (1-216 aa encoded by BC013348)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize both RAB11A (24 kDa) and RAB11B(24 kDa).

Immunogen sequence: MGTRDDEYD YLFKVVLIGD SGVGKSNLLS RFTRNEFNLE SKSTIGVEFA TRSIQVDGKT IKAQIWDTAG QERYRAITSA YYRGAVGALL VYDIAKHLTY ENVERWLKEL RDHADSNIVI MLVGNKSDLR HLRAVPTDEA RAFAEKNGLS FIETSALDST NVEAAFQTIL TEIYRIVSQK QMSDRRENDM SPSNNVVPIH VPPTTENKPK VQCCQNI (1-216 aa encoded by BC013348)

Target Information

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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eLife

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Tue Apr 04 00:00:00 EDT 2023

KIF13B mediates VEGFR2 recycling to modulate vascular permeability.

Cellular and molecular life sciences : CMLS

Cho HD,Nhàn NTT,Zhou C,Tu K,Nguyen T,Sarich NA,Yamada KH

Thu Mar 16 00:00:00 EDT 2023

KIF13B mediates VEGFR2 recycling to modulate vascular permeability.

Cellular and molecular life sciences : CMLS

Cho HD,Nhàn NTT,Zhou C,Tu K,Nguyen T,Sarich NA,Yamada KH

Thu Mar 16 00:00:00 EDT 2023

Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy.

Frontiers in pharmacology

Zhang H,Fu T,Sun J,Zou S,Qiu S,Zhang J,Su S,Shi C,Li DP,Xu Y

Wed Sep 07 00:00:00 EDT 2022

Porcine Circovirus Type 3 Enters Into PK15 Cells Through Clathrin- and Dynamin-2-Mediated Endocytosis in a Rab5/Rab7 and pH-Dependent Fashion.

Frontiers in microbiology

Shi R,Hou L,Wei L,Quan R,Zhou B,Jiang H,Wang J,Zhu S,Song J,Wang D,Liu J

Wed Mar 10 00:00:00 EST 2021

Endosomal recycling tubule scission and integrin recycling involve the membrane curvature-supporting protein LITAF.

Journal of cell science

Wunderley L,Zhang L,Yarwood R,Qin W,Lowe M,Woodman P

Sun Aug 01 00:00:00 EDT 2021

Endocytic recycling as cellular trafficking fate of simvastatin-loaded discoidal reconstituted high-density lipoprotein to coordinate cholesterol efflux and drug influx.

Nanomedicine : nanotechnology, biology, and medicine

Qi Z,Jiang C,Gao H,Wang Y,Zhang Q,Zhang W,Liu J

Mon Feb 01 00:00:00 EST 2021

Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling.

Journal of oncology

Du J,Fu L,Hao J,Lin X,Dong Q

Fri Nov 13 00:00:00 EST 2020

Rab11a Is Overexpressed in Gastric Cancer and Regulates FAK/AKT Signaling.

Journal of oncology

Du J,Fu L,Hao J,Lin X,Dong Q

Fri Nov 13 00:00:00 EST 2020

ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction.

Clinical and translational medicine

Sun X,Shu Y,Xu M,Jiang J,Wang L,Wang J,Huang D,Zhang J

Thu Oct 01 00:00:00 EDT 2020

ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction.

Clinical and translational medicine

Sun X,Shu Y,Xu M,Jiang J,Wang L,Wang J,Huang D,Zhang J

Thu Oct 01 00:00:00 EDT 2020

ANXA6 suppresses the tumorigenesis of cervical cancer through autophagy induction.

Clinical and translational medicine

Sun X,Shu Y,Xu M,Jiang J,Wang L,Wang J,Huang D,Zhang J

Thu Oct 01 00:00:00 EDT 2020

ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chan WWR,Li W,Chang RCC,Lau KF

Tue Dec 01 00:00:00 EST 2020

ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chan WWR,Li W,Chang RCC,Lau KF

Tue Dec 01 00:00:00 EST 2020

Zika virus: mapping and reprogramming the entry.

Cell communication and signaling : CCS

Owczarek K,Chykunova Y,Jassoy C,Maksym B,Rajfur Z,Pyrc K

Fri May 03 00:00:00 EDT 2019

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM.

Brain, behavior, and immunity

Storck SE,Hartz AMS,Bernard J,Wolf A,Kachlmeier A,Mahringer A,Weggen S,Pahnke J,Pietrzik CU

Mon Oct 01 00:00:00 EDT 2018

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM.

Brain, behavior, and immunity

Storck SE,Hartz AMS,Bernard J,Wolf A,Kachlmeier A,Mahringer A,Weggen S,Pahnke J,Pietrzik CU

Mon Oct 01 00:00:00 EDT 2018

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.

Veterinary research

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Tue Jul 03 00:00:00 EDT 2018

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.

Veterinary research

Szczepanski A,Owczarek K,Milewska A,Baster Z,Rajfur Z,Mitchell JA,Pyrc K

Tue Jul 03 00:00:00 EDT 2018

Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-κB) Signaling Pathway in Human Bladder Carcinoma.

Medical science monitor : international medical journal of experimental and clinical research

Gong X,Liu J,Zhang X,Dong F,Liu Y,Wang P

Sun Jul 22 00:00:00 EDT 2018

Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-κB) Signaling Pathway in Human Bladder Carcinoma.

Medical science monitor : international medical journal of experimental and clinical research

Gong X,Liu J,Zhang X,Dong F,Liu Y,Wang P

Sun Jul 22 00:00:00 EDT 2018

Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-κB) Signaling Pathway in Human Bladder Carcinoma.

Medical science monitor : international medical journal of experimental and clinical research

Gong X,Liu J,Zhang X,Dong F,Liu Y,Wang P

Sun Jul 22 00:00:00 EDT 2018

Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-κB) Signaling Pathway in Human Bladder Carcinoma.

Medical science monitor : international medical journal of experimental and clinical research

Gong X,Liu J,Zhang X,Dong F,Liu Y,Wang P

Sun Jul 22 00:00:00 EDT 2018

Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Wang H,Wang G,Gao Y,Zhao C,Li X,Zhang F,Jiang C,Wu B

Fri Sep 14 00:00:00 EDT 2018

Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Wang H,Wang G,Gao Y,Zhao C,Li X,Zhang F,Jiang C,Wu B

Fri Sep 14 00:00:00 EDT 2018

Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.

Journal of experimental & clinical cancer research : CR

Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

Tue Oct 16 00:00:00 EDT 2018

Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.

Journal of experimental & clinical cancer research : CR

Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

Tue Oct 16 00:00:00 EDT 2018

Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma.

Oncogene

Zhang W,Hong R,Xue L,Ou Y,Liu X,Zhao Z,Xiao W,Dong D,Dong L,Fu M,Ma L,Lu N,Chen H,Song Y,Zhan Q

Thu Jul 06 00:00:00 EDT 2017

Piccolo mediates EGFR signaling and acts as a prognostic biomarker in esophageal squamous cell carcinoma.

Oncogene

Zhang W,Hong R,Xue L,Ou Y,Liu X,Zhao Z,Xiao W,Dong D,Dong L,Fu M,Ma L,Lu N,Chen H,Song Y,Zhan Q

Thu Jul 06 00:00:00 EDT 2017

Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly.

Journal of virology

Cifuentes-Muñoz N,Sun W,Ray G,Schmitt PT,Webb S,Gibson K,Dutch RE,Schmitt AP

Sat Jul 15 00:00:00 EDT 2017

Mutations in the Transmembrane Domain and Cytoplasmic Tail of Hendra Virus Fusion Protein Disrupt Virus-Like-Particle Assembly.

Journal of virology

Cifuentes-Muñoz N,Sun W,Ray G,Schmitt PT,Webb S,Gibson K,Dutch RE,Schmitt AP

Sat Jul 15 00:00:00 EDT 2017

Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.

Oncotarget

Dong Q,Fu L,Zhao Y,Du Y,Li Q,Qiu X,Wang E

Tue Apr 25 00:00:00 EDT 2017

Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.

Oncotarget

Dong Q,Fu L,Zhao Y,Du Y,Li Q,Qiu X,Wang E

Tue Apr 25 00:00:00 EDT 2017

Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.

Oncotarget

Dong Q,Fu L,Zhao Y,Du Y,Li Q,Qiu X,Wang E

Tue Apr 25 00:00:00 EDT 2017

Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer.

Oncotarget

Dong Q,Fu L,Zhao Y,Du Y,Li Q,Qiu X,Wang E

Tue Apr 25 00:00:00 EDT 2017

Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion.

The Journal of cell biology

Dolat L,Spiliotis ET

Mon Aug 29 00:00:00 EDT 2016

Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion.

The Journal of cell biology

Dolat L,Spiliotis ET

Mon Aug 29 00:00:00 EDT 2016

Rab11a sustains GSK3β/Wnt/β-catenin signaling to enhance cancer progression in pancreatic cancer.