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Product Details
20228-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to RAB5A. It has no cross reaction to RAB5B or RAB5C.
Target Information
RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Rab 5; Rab 5A; Ras related protein; RAS-associated protein RAB5A; Ras-related protein Rab-5A
Gene Aliases: 2410015H04Rik; AI663973; AU021172; nnyRab5a; RAB5; RAB5A
UniProt ID: (Human) P20339, (Mouse) Q9CQD1
Entrez Gene ID: (Human) 5868, (Mouse) 271457
endocytosis
phagocytosis
small GTPase mediated signal transduction
blood coagulation
protein transport
regulation of endocytosis
synaptic vesicle recycling
early endosome to late endosome transport
positive regulation of exocytosis
regulation of endosome size
regulation of filopodium assembly
receptor internalization involved in canonical Wnt signaling pathway
regulation of synaptic vesicle exocytosis
regulation of autophagosome assembly
transport
intracellular protein transport
endosome organization
positive regulation of smooth muscle cell migration
Rab protein signal transduction
regulation of long-term neuronal synaptic plasticity
positive regulation of smooth muscle cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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