Proteintech

RAB7A Polyclonal Antibody

RAB7A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 13

RAB7A Antibody (55469-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 55469-1-AP (RAB7A antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

RAB7A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

55469-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 14 publications 14 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to RAB7A.

Target Information

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Thu Apr 27 00:00:00 EDT 2023

Porcine Enteric Alphacoronavirus Entry through Multiple Pathways (Caveolae, Clathrin, and Macropinocytosis) Requires Rab GTPases for Endosomal Transport.

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25-hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.

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25-hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.

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The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.

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The COPS3-FOXO3 positive feedback loop regulates autophagy to promote cisplatin resistance in osteosarcoma.

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Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.

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SARS-CoV-2 triggers Golgi fragmentation via down-regulation of GRASP55 to facilitate viral trafficking.

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Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.

Aging

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Synergism between upregulation of Rab7 and inhibition of autophagic degradation caused by mycoplasma facilitates intracellular mycoplasma infection.

Molecular medicine reports

Hu X,Yu J,Zhou X,Li Z,Xia Y,Luo Z,Wu Y

Sat Mar 01 00:00:00 EST 2014

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Bioinformatics

Protein Aliases: rab-7; RAB7, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein BRL-RAS; Ras-related protein p23; Ras-related protein Rab-7a

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Gene Aliases: PRO2706; RAB7; RAB7A

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UniProt ID: (Human) P51149, (Mouse) P51150, (Rat) P09527

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Entrez Gene ID: (Human) 7879, (Mouse) 19349, (Rat) 29448

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Function(s)

GTPase activity protein binding GTP binding GDP binding Rac GTPase binding nucleotide binding

Process(es)

protein targeting to lysosome transport intracellular protein transport epidermal growth factor catabolic process small GTPase mediated signal transduction endosome to lysosome transport protein transport viral release from host cell protein to membrane docking Rab protein signal transduction retrograde transport, endosome to Golgi early endosome to late endosome transport bone resorption positive regulation of protein catabolic process positive regulation of viral process phagosome acidification phagosome-lysosome fusion positive regulation of exosomal secretion regulation of autophagosome assembly endocytosis antigen processing and presentation of exogenous peptide antigen via MHC class II lipophagy phagosome maturation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAB7A Polyclonal Antibody

RAB7A Antibody (55469-1-AP) in IHC (P)

Product Details

55469-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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