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Product Details
PA5-109239
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human RAB7 aa 43-200
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854650
Product Specific Information
Positive Control: MCF-7, A431, SiHa, rat brain tissue, human tonsil tissue, human liver tissue, human colon cancer tissue, mouse colon tissue.
Target Information
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: rab-7; RAB7, member RAS oncogene family; Ras-associated protein RAB7; Ras-related protein Rab-7a
Gene Aliases: PRO2706; RAB7; RAB7A
UniProt ID: (Human) P51149
Entrez Gene ID: (Human) 7879
protein targeting to lysosome
endocytosis
epidermal growth factor catabolic process
small GTPase mediated signal transduction
endosome to lysosome transport
protein transport
viral release from host cell
antigen processing and presentation of exogenous peptide antigen via MHC class II
protein to membrane docking
retrograde transport, endosome to Golgi
early endosome to late endosome transport
bone resorption
positive regulation of protein catabolic process
positive regulation of viral process
lipophagy
phagosome maturation
phagosome acidification
phagosome-lysosome fusion
positive regulation of exosomal secretion
regulation of autophagosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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