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Invitrogen
RAC2 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
RAC2 Antibody (PA5-29681) in IHC (P)
RAC2 Polyclonal Antibody detects RAC2 protein at cytosol on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. RAC2 Polyclonal Antibody (Product # PA5-29681) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29681
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 189 of Human RAC2
Conjugate
Form
Liquid
Concentration
1.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547156
Product Specific Information
Recommended positive controls: Molt-4, Raji.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (96%), Drosophila (92%), Xenopus laevis (96%), Chicken (99%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EN-7 protein; GX; p21-Rac2; Protein EN-7; Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Small G protein
Gene Aliases: AI323801; AI452260; EN-7; Gx; HSPC022; p21-Rac2; RAC2
UniProt ID: (Human) P15153, (Mouse) Q05144
Entrez Gene ID: (Human) 5880, (Mouse) 19354
chemotaxis
actin filament organization
signal transduction
G-protein coupled receptor signaling pathway
small GTPase mediated signal transduction
positive regulation of cell proliferation
regulation of hydrogen peroxide metabolic process
positive regulation of lamellipodium assembly
regulation of cell-substrate adhesion
cell projection assembly
platelet activation
regulation of T cell proliferation
regulation of mast cell degranulation
bone resorption
regulation of protein kinase activity
regulation of small GTPase mediated signal transduction
regulation of respiratory burst
regulation of mast cell chemotaxis
lymphocyte aggregation
positive regulation of neutrophil chemotaxis
regulation of neutrophil migration
positive regulation of protein targeting to mitochondrion
actin cytoskeleton organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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