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RAC2 Monoclonal Antibody (4C2H6)

RAC2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

RAC2 Antibody (60077-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using (Product # 60077-1-IG) (RAC2 antibody) at dilution of 1:8000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

60077-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4C2H6

Immunogen

RAC2 Fusion Protein Ag1202 (1-192 aa encoded by BC001485)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.5 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MQAIKCVVV GDGAVGKTCL LISYTTNAFP GEYIPTVFDN YSANVMVDSK PVNLGLWDTA GQEDYDRLRP LSYPQTDVFL ICFSLVSPAS YENVRAKWFP EVRHHCPSTP IILVGTKLDL RDDKDTIEKL KEKKLAPITY PQGLALAKEI DSVKYLECSA LTQRGLKTVF DEAIRAVLCP QPTRQQKRAC SLL (1-192 aa encoded by BC001485)

Target Information

RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.

Cellular & molecular immunology

Ma X,Tan X,Yu B,Sun W,Wang H,Hu H,Du Y,He R,Gao R,Peng Q,Cui Z,Pan T,Feng X,Wang J,Xu C,Zhu B,Liu W,Wang C

Sun May 01 00:00:00 EDT 2022

DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.

Cellular & molecular immunology

Ma X,Tan X,Yu B,Sun W,Wang H,Hu H,Du Y,He R,Gao R,Peng Q,Cui Z,Pan T,Feng X,Wang J,Xu C,Zhu B,Liu W,Wang C

Sun May 01 00:00:00 EDT 2022

A γ-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease.

Progress in neurobiology

Xiong M,Zou L,Meng L,Zhang X,Tian Y,Zhang G,Yang J,Chen G,Xiong J,Ye K,Zhang Z

Sun Aug 01 00:00:00 EDT 2021

Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.

ACS nano

Kang Y,Liu J,Yin S,Jiang Y,Feng X,Wu J,Zhang Y,Chen A,Zhang Y,Shao L

Tue Mar 24 00:00:00 EDT 2020

Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.

ACS nano

Kang Y,Liu J,Yin S,Jiang Y,Feng X,Wu J,Zhang Y,Chen A,Zhang Y,Shao L

Tue Mar 24 00:00:00 EDT 2020

Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.

Cancer medicine

Zhang X,Fang J,Chen S,Wang W,Meng S,Liu B

Sun Sep 01 00:00:00 EDT 2019

Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.

Cancer medicine

Zhang X,Fang J,Chen S,Wang W,Meng S,Liu B

Sun Sep 01 00:00:00 EDT 2019

RAC2 acts as a prognostic biomarker and promotes the progression of clear cell renal cell carcinoma.

International journal of oncology

Liu Y,Cheng G,Song Z,Xu T,Ruan H,Cao Q,Wang K,Bao L,Liu J,Zhou L,Liu D,Yang H,Chen K,Zhang X

Sun Sep 01 00:00:00 EDT 2019

RAC2 acts as a prognostic biomarker and promotes the progression of clear cell renal cell carcinoma.

International journal of oncology

Liu Y,Cheng G,Song Z,Xu T,Ruan H,Cao Q,Wang K,Bao L,Liu J,Zhou L,Liu D,Yang H,Chen K,Zhang X

Sun Sep 01 00:00:00 EDT 2019

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Science signaling

Campa CC,Germena G,Ciraolo E,Copperi F,Sapienza A,Franco I,Ghigo A,Camporeale A,Di Savino A,Martini M,Perino A,Megens RT,Kurz AR,Scheiermann C,Sperandio M,Gamba A,Hirsch E

Tue Dec 20 00:00:00 EST 2016

Rac signal adaptation controls neutrophil mobilization from the bone marrow.

Science signaling

Campa CC,Germena G,Ciraolo E,Copperi F,Sapienza A,Franco I,Ghigo A,Camporeale A,Di Savino A,Martini M,Perino A,Megens RT,Kurz AR,Scheiermann C,Sperandio M,Gamba A,Hirsch E

Tue Dec 20 00:00:00 EST 2016

Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.

Oncotarget

Bo H,Gong Z,Zhang W,Li X,Zeng Y,Liao Q,Chen P,Shi L,Lian Y,Jing Y,Tang K,Li Z,Zhou Y,Zhou M,Xiang B,Li X,Yang J,Xiong W,Li G,Zeng Z

Fri Aug 21 00:00:00 EDT 2015

Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma.

Oncotarget

Bo H,Gong Z,Zhang W,Li X,Zeng Y,Liao Q,Chen P,Shi L,Lian Y,Jing Y,Tang K,Li Z,Zhou Y,Zhou M,Xiang B,Li X,Yang J,Xiong W,Li G,Zeng Z

Fri Aug 21 00:00:00 EDT 2015

Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.

The Journal of experimental medicine

Morrison AR,Yarovinsky TO,Young BD,Moraes F,Ross TD,Ceneri N,Zhang J,Zhuang ZW,Sinusas AJ,Pardi R,Schwartz MA,Simons M,Bender JR

Mon Sep 22 00:00:00 EDT 2014

Chemokine-coupled β2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis.

The Journal of experimental medicine

Morrison AR,Yarovinsky TO,Young BD,Moraes F,Ross TD,Ceneri N,Zhang J,Zhuang ZW,Sinusas AJ,Pardi R,Schwartz MA,Simons M,Bender JR

Mon Sep 22 00:00:00 EDT 2014

The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.

The Journal of biological chemistry

Cavnar PJ,Mogen K,Berthier E,Beebe DJ,Huttenlocher A

Fri Jul 20 00:00:00 EDT 2012

The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis.

The Journal of biological chemistry

Cavnar PJ,Mogen K,Berthier E,Beebe DJ,Huttenlocher A

Fri Jul 20 00:00:00 EDT 2012

Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Wang ZJ,Song L,Guo LC,Yin M,Sun YN

Thu Jan 05 00:00:00 EST 2012

Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Wang ZJ,Song L,Guo LC,Yin M,Sun YN

Thu Jan 05 00:00:00 EST 2012

Bioinformatics

Protein Aliases: EN-7 protein; GX; p21-Rac2; Protein EN-7; RAS-related C3 botulinum substrate 2; Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Small G protein

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Gene Aliases: AI323801; AI452260; EN-7; Gx; HSPC022; p21-Rac2; RAC2

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UniProt ID: (Human) P15153, (Mouse) Q05144

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Entrez Gene ID: (Human) 5880, (Rat) 366957, (Mouse) 19354

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Function(s)

GTPase activity GTP binding protein kinase regulator activity nucleotide binding small GTPase

Process(es)

chemotaxis actin filament organization signal transduction G-protein coupled receptor signaling pathway small GTPase mediated signal transduction positive regulation of cell proliferation regulation of hydrogen peroxide metabolic process positive regulation of lamellipodium assembly regulation of cell-substrate adhesion cell projection assembly platelet activation regulation of T cell proliferation regulation of mast cell degranulation bone resorption regulation of protein kinase activity regulation of small GTPase mediated signal transduction regulation of respiratory burst regulation of mast cell chemotaxis lymphocyte aggregation positive regulation of neutrophil chemotaxis regulation of neutrophil migration positive regulation of protein targeting to mitochondrion metabolic process actin cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RAC2 Monoclonal Antibody (4C2H6)

RAC2 Antibody (60077-1-IG) in IHC (P)

Product Details

60077-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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