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Product Details
PA5-29698
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 395 and 632 of Human RACGAP1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547172
Product Specific Information
Recommended positive controls: 293T, A431, Jurkat, Raji.
Predicted reactivity: Mouse (81%), Rat (82%), Rhesus Monkey (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AKT; CYK4; ID; Male germ cell RacGap; MGC99656; MgcRacGAP; PKB-ALPHA; PRKBA; protein CYK4 homolg; Protein CYK4 homolog; RAC; Rac GTPase-activating protein 1; RAC-ALPHA
Gene Aliases: CYK4; HsCYK-4; ID-GAP; KIAA1478; MGCRACGAP; RACGAP1
UniProt ID: (Human) Q9H0H5
Entrez Gene ID: (Human) 29127
mitotic cytokinesis
actomyosin contractile ring assembly
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
spermatogenesis
neuroblast proliferation
sulfate transport
embryo development
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of cytokinesis
intracellular signal transduction
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
mitotic spindle midzone assembly
regulation of attachment of spindle microtubules to kinetochore
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