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RACGAP1 Antibody (TA811641) in IHC (P)
Immunohistochemical staining of paraffin-embedded human spleen tissue within the normal limits using anti-RACGAP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA811641)(1:500).
Product Details
TA811641
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4H8
Immunogen
Human recombinant protein fragment corresponding to amino acids 123-238 of human RACGAP1 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AKT; CYK4; ID; Male germ cell RacGap; MGC99656; MgcRacGAP; PKB-ALPHA; PRKBA; protein CYK4 homolg; Protein CYK4 homolog; RAC; Rac GTPase-activating protein 1; RAC-ALPHA
Gene Aliases: CYK4; HsCYK-4; ID-GAP; KIAA1478; MGCRACGAP; RACGAP1
UniProt ID: (Human) Q9H0H5
Entrez Gene ID: (Human) 29127
mitotic cytokinesis
actomyosin contractile ring assembly
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
spermatogenesis
neuroblast proliferation
sulfate transport
embryo development
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of cytokinesis
intracellular signal transduction
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
mitotic spindle midzone assembly
regulation of attachment of spindle microtubules to kinetochore
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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