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Product Details
PA1-29451
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide KYDPTIEDSYRKQVEVDC conjugated to KLH, corresponding to amino acids 31-48 of Human RAP1a.
Conjugate
Form
Liquid
Concentration
0.95 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1960314
Product Specific Information
It is expected to cross-react with zebrafish and C. elegans based on sequence homology of 100% and 94%, respectively.
PA1-29451 has been successfully used in Western blot applications where a band of 25 kDa is detected. Positive control: rat brain tissue extract.
Target Information
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C21KG; G-22K; GTP-binding protein smg p21A; GTP-binding protein SMG-P21A; RAS-related protein 1a; Ras-related protein Krev-1; Ras-related protein Rap-1A
Gene Aliases: AI848598; C21KG; G-22K; KREV-1; KREV1; rap 1A; RAP-1A; RAP1; RAP1A; SMGP21
UniProt ID: (Human) P62834, (Mouse) P62835, (Rat) P62836
Entrez Gene ID: (Rabbit) 100351588, (Human) 5906, (Mouse) 109905, (Rat) 295347
activation of MAPKK activity
signal transduction
positive regulation of neuron projection development
protein transport
microvillus assembly
Rap protein signal transduction
negative regulation of collagen biosynthetic process
cellular response to drug
nerve growth factor signaling pathway
positive regulation of GTPase activity
positive regulation of protein kinase activity
positive regulation of glucose import
positive regulation of phagocytosis
regulation of insulin secretion
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to glucose stimulus
response to antineoplastic agent
liver regeneration
regulation of cell junction assembly
cellular response to nerve growth factor stimulus
negative regulation of synaptic vesicle exocytosis
positive regulation of vasculogenesis
small GTPase mediated signal transduction
nervous system development
metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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