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Product Details
PA5-86727
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the 525-570 of Human RAP1GAP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2803487
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARPP-90; Rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1GAP
Gene Aliases: 1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; KIAA0474; RAP1GA1; RAP1GAP; RAP1GAP1; RAP1GAPII; RAPGAP
UniProt ID: (Human) P47736, (Mouse) A2ALS5
Entrez Gene ID: (Human) 5909, (Mouse) 110351
signal transduction
regulation of GTPase activity
positive regulation of GTPase activity
negative regulation of neuron differentiation
regulation of small GTPase mediated signal transduction
negative regulation of microvillus assembly
negative regulation of GTP binding
negative regulation of thyroid gland epithelial cell proliferation
cellular response to glial cell derived neurotrophic factor
negative regulation of cell proliferation
Performance Guarantee
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