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Product Details
BS-6576R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human RBBP6, amino acids 1201-1350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RBBP6; p53-associated cellular protein of testis; Proliferation potential-related protein; Protein P2P-R; RB-binding Q-protein 1; RBQ-1; retinoblastoma binding protein 6; Retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; Retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6
Gene Aliases: 4933422O15Rik; AI316869; BB233631; C030034J04Rik; C77662; MY038; P2P-R; P2PR; PACT; RBBP6; RBQ-1; RBQ1; SNAMA
UniProt ID: (Human) Q7Z6E9, (Mouse) P97868
Entrez Gene ID: (Human) 5930, (Mouse) 19647, (Rat) 308968
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
poly(A) RNA binding
ubiquitin protein ligase activity
nucleic acid binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
transporter
ubiquitin-protein ligase
protein modifying enzyme
protein polyubiquitination
in utero embryonic development
DNA replication
regulation of DNA replication
mRNA processing
cellular response to DNA damage stimulus
multicellular organism growth
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
embryonic organ development
somite development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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