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Product Details
PA5-59697
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RBBP6. Recombinant protein control fragment (Product #RP-102914).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2646354
Product Specific Information
Immunogen sequence: KATYDTKRPN EETKSVDKNP CKDREKHVLE ARNNKESSGN KLLYILNPPE TQVEKEQITG QIDKSTVKPK PQLSHSSRLS SDLTRETDEA AFEPD
Highest antigen sequence identity to the following orthologs: Mouse - 75%, Rat - 75%.
Target Information
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RBBP6; p53-associated cellular protein of testis; Proliferation potential-related protein; Protein P2P-R; RB-binding Q-protein 1; RBQ-1; retinoblastoma binding protein 6; Retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; Retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6
Gene Aliases: MY038; P2P-R; P2PR; PACT; RBBP6; RBQ-1; RBQ1; SNAMA
UniProt ID: (Human) Q7Z6E9
Entrez Gene ID: (Human) 5930
protein polyubiquitination
in utero embryonic development
DNA replication
regulation of DNA replication
mRNA processing
cellular response to DNA damage stimulus
multicellular organism growth
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
embryonic organ development
somite development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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