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RBP4 Polyclonal Antibody

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Antibody Testing Data (14)

RBP4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RBP4 Antibody (11774-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue slide using (Product # 11774-1-AP) RBP4 antibody at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

RBP4 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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Product Details

11774-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:500

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Avian, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RBP4 Fusion Protein Ag2448 (1-201 aa encoded by BC020633)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKWVWALFL LAALGSGRAE RDCRVSSFRV KENFDKARFS GTWYAMAKKD PEGLFLQDNI VAEFSVDETG QMSATAKGRV RLLNNWDVCA DMVGTFTDTE DPAKFKMKYW GVASFLQKGN DDHWIVDTDY DTYAVQYSCR LLNLDGTCAD SYSFVFSRDP NGLPPEAQKI VRQRQEELCL ARQYRLIVHN GYCDGRSERN LL (1-201 aa encoded by BC020633)

Target Information

This protein belongs to the lipocalin family and is the specific carrier for retinol in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein post translationally and results in defective delivery and supply to the epidermal cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport.

Frontiers in cell and developmental biology

Radhakrishnan R,Leung M,Solanki AK,Lobo GP

Tue Apr 18 00:00:00 EDT 2023

Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport.

Frontiers in cell and developmental biology

Radhakrishnan R,Leung M,Solanki AK,Lobo GP

Tue Apr 18 00:00:00 EDT 2023

RBP4 regulates androgen receptor expression and steroid synthesis in Sertoli cells from Bactrian camels.

Reproduction in domestic animals = Zuchthygiene

Wang Q,Zhang Q,Li Y,Zhao X,Zhang Y

Fri Apr 01 00:00:00 EDT 2022

RBP4 regulates androgen receptor expression and steroid synthesis in Sertoli cells from Bactrian camels.

Reproduction in domestic animals = Zuchthygiene

Wang Q,Zhang Q,Li Y,Zhao X,Zhang Y

Fri Apr 01 00:00:00 EDT 2022

RBP4 regulates androgen receptor expression and steroid synthesis in Sertoli cells from Bactrian camels.

Reproduction in domestic animals = Zuchthygiene

Wang Q,Zhang Q,Li Y,Zhao X,Zhang Y

Fri Apr 01 00:00:00 EDT 2022

A novel regulatory mechanism of geniposide for improving glucose homeostasis mediated by circulating RBP4.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Liu J,Song C,Nie C,Sun Y,Wang Y,Xue L,Fan M,Qian H,Wang L,Li Y

Sat Jan 01 00:00:00 EST 2022

Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4.

Theranostics

Liu J,Nie C,Xue L,Yan Y,Liu S,Sun J,Fan M,Qian H,Ying H,Wang L,Li Y

Wed Jan 19 00:00:00 EST 2022

Retinoid Regulation of Ocular Surface Innate Inflammation.

International journal of molecular sciences

Alam J,Yu Z,de Paiva CS,Pflugfelder SC

Fri Jan 22 00:00:00 EST 2021

Bio-inspired chiral self-assemblies promoted neuronal differentiation of retinal progenitor cells through activation of metabolic pathway.

Bioactive materials

Sun N,Dou X,Tang Z,Zhang D,Ni N,Wang J,Gao H,Ju Y,Dai X,Zhao C,Gu P,Ji J,Feng C

Thu Apr 01 00:00:00 EDT 2021

Bio-inspired chiral self-assemblies promoted neuronal differentiation of retinal progenitor cells through activation of metabolic pathway.

Bioactive materials

Sun N,Dou X,Tang Z,Zhang D,Ni N,Wang J,Gao H,Ju Y,Dai X,Zhao C,Gu P,Ji J,Feng C

Thu Apr 01 00:00:00 EDT 2021

Altering retinol binding protein 4 levels in hepatitis C: Inflammation and steatosis matter.

Virulence

Chang ML,Chen WT,Hu JH,Chen SC,Gu PW,Chien RN

Tue Dec 01 00:00:00 EST 2020

Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.

Metabolism: clinical and experimental

Shin SJ,Chen CH,Kuo WC,Chan HC,Chan HC,Lin KD,Ke LY

Tue Dec 01 00:00:00 EST 2020

Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.

Metabolism: clinical and experimental

Shin SJ,Chen CH,Kuo WC,Chan HC,Chan HC,Lin KD,Ke LY

Tue Dec 01 00:00:00 EST 2020

Screening for reproductive biomarkers in Bactrian camel via iTRAQ analysis of proteomes.

Reproduction in domestic animals = Zuchthygiene

Wang Q,Zhang Q,Gan Z,Li H,Yang Y,Zhang Y,Zhao X

Sat Feb 01 00:00:00 EST 2020

Inhibitory effect of chitooligosaccharides on retinol metabolism and bioavailability in mice.

Journal of food biochemistry

Li W,Zhao M,Qin Z,Chen Q,Fan L,Zhou J,Zhao L

Wed May 01 00:00:00 EDT 2019

Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients.

Emerging microbes & infections

Wang J,Zhu X,Xiong X,Ge P,Liu H,Ren N,Khan FA,Zhou X,Zhang L,Yuan X,Chen X,Chen Y,Hu C,Robertson ID,Chen H,Guo A

Wed Apr 11 00:00:00 EDT 2018

Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients.

Emerging microbes & infections

Wang J,Zhu X,Xiong X,Ge P,Liu H,Ren N,Khan FA,Zhou X,Zhang L,Yuan X,Chen X,Chen Y,Hu C,Robertson ID,Chen H,Guo A

Wed Apr 11 00:00:00 EDT 2018

Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.

Reproductive biology and endocrinology : RB&E

Jiang Y,Zhao Y,Chen S,Chen L,Li C,Zhou X

Tue Mar 20 00:00:00 EDT 2018

Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.

Reproductive biology and endocrinology : RB&E

Jiang Y,Zhao Y,Chen S,Chen L,Li C,Zhou X

Tue Mar 20 00:00:00 EDT 2018

Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.

Reproductive biology and endocrinology : RB&E

Jiang Y,Zhao Y,Chen S,Chen L,Li C,Zhou X

Tue Mar 20 00:00:00 EDT 2018

Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary.

Reproductive biology and endocrinology : RB&E

Jiang Y,Zhao Y,Chen S,Chen L,Li C,Zhou X

Tue Mar 20 00:00:00 EDT 2018

Comparative proteomic analysis of ovaries from Huoyan geese between pre-laying and laying periods using an iTRAQ-based approach.

Poultry science

Cao Z,Meng B,Fan R,Liu M,Gao M,Xing Z,Luan X

Fri Jun 01 00:00:00 EDT 2018

Comparative proteomic analysis of ovaries from Huoyan geese between pre-laying and laying periods using an iTRAQ-based approach.

Poultry science

Cao Z,Meng B,Fan R,Liu M,Gao M,Xing Z,Luan X

Fri Jun 01 00:00:00 EDT 2018

Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus.

Laboratory investigation; a journal of technical methods and pathology

Liu L,Suzuki T,Shen J,Wakana S,Araki K,Yamamura KI,Lei L,Li Z

Sat Apr 01 00:00:00 EDT 2017

Rescue of retinal morphology and function in a humanized mouse at the mouse retinol-binding protein locus.

Laboratory investigation; a journal of technical methods and pathology

Liu L,Suzuki T,Shen J,Wakana S,Araki K,Yamamura KI,Lei L,Li Z

Sat Apr 01 00:00:00 EDT 2017

N-Glycoform-dependent interactions of megalin with its ligands.

Biochimica et biophysica acta. General subjects

Hirano M,Totani K,Fukuda T,Gu J,Suzuki A

Sun Jan 01 00:00:00 EST 2017

N-Glycoform-dependent interactions of megalin with its ligands.

Biochimica et biophysica acta. General subjects

Hirano M,Totani K,Fukuda T,Gu J,Suzuki A

Sun Jan 01 00:00:00 EST 2017

N-Glycoform-dependent interactions of megalin with its ligands.

Biochimica et biophysica acta. General subjects

Hirano M,Totani K,Fukuda T,Gu J,Suzuki A

Sun Jan 01 00:00:00 EST 2017

N-Glycoform-dependent interactions of megalin with its ligands.

Biochimica et biophysica acta. General subjects

Hirano M,Totani K,Fukuda T,Gu J,Suzuki A

Sun Jan 01 00:00:00 EST 2017

Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background.

Laboratory investigation; a journal of technical methods and pathology

Shen J,Shi D,Suzuki T,Xia Z,Zhang H,Araki K,Wakana S,Takeda N,Yamamura K,Jin S,Li Z

Wed Jun 01 00:00:00 EDT 2016

Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background.

Laboratory investigation; a journal of technical methods and pathology

Shen J,Shi D,Suzuki T,Xia Z,Zhang H,Araki K,Wakana S,Takeda N,Yamamura K,Jin S,Li Z

Wed Jun 01 00:00:00 EDT 2016

Identification of low-abundance proteins via fractionation of the urine proteome with weak anion exchange chromatography.

Proteome science

Lu CM,Wu YJ,Chen CC,Hsu JL,Chen JC,Chen JY,Huang CH,Ko YC

Fri Apr 08 00:00:00 EDT 2011

Identification of low-abundance proteins via fractionation of the urine proteome with weak anion exchange chromatography.

Proteome science

Lu CM,Wu YJ,Chen CC,Hsu JL,Chen JC,Chen JY,Huang CH,Ko YC

Fri Apr 08 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: Plasma retinol binding protein 4 (PRBP); Plasma retinol-binding protein; PRBP; RBP; retinol; retinol binding; Retinol binding protein 4 interstitial; retinol binding protein 4, cellular; retinol binding protein 4, plasma; Retinol-binding protein 4; retinol-binding protein 4, interstitial

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Gene Aliases: MCOPCB10; PRO2222; Rbp-4; RBP4; RBPA; RDCCAS

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UniProt ID: (Human) P02753, (Rat) P04916, (Mouse) Q00724

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Entrez Gene ID: (Human) 5950, (Rat) 25703, (Mouse) 19662

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Function(s)

protein binding retinal binding retinol binding retinol transporter activity protein heterodimerization activity transporter activity retinoid binding small molecule binding transfer/carrier protein

Process(es)

retinoid metabolic process eye development gluconeogenesis heart development visual perception maintenance of gastrointestinal epithelium lung development positive regulation of insulin secretion response to retinoic acid retinol transport retinol metabolic process glucose homeostasis response to ethanol embryonic organ morphogenesis embryonic skeletal system development cardiac muscle tissue development female genitalia morphogenesis positive regulation of immunoglobulin secretion negative regulation of cardiac muscle cell proliferation embryonic retina morphogenesis in camera-type eye uterus development vagina development urinary bladder development heart trabecula formation transport spermatogenesis male gonad development response to insulin retinal metabolic process detection of light stimulus involved in visual perception vitamin transport retina development in camera-type eye embryo development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RBP4 Polyclonal Antibody

RBP4 Antibody (11774-1-AP) in IHC (P)

Product Details

11774-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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