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Product Details
14613-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RBPJ Fusion Protein Ag6206 (138-486 aa encoded by BC064976)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DIGVFLSKR IKVISKPSKK KQSLKNADLC IASGTKVALF NRLRSQTVST RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG YIHYGQTVKL VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP VTPVPVVESL QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES MLCVVPDISA FREGWRWVRQ PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP RPHCSAAGAI LRANSSQVPP NESNTNSEGS YTNASTNSTS VTSSTATVVS (138-486 aa encoded by BC064976)
Target Information
CSL plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The protein is abundantly expressed in heart and skeletal muscle and expression is increased by passive stretch. Mutations in this gene can lead to X-linked deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CBF-1; H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; J kappa-recombination signal-binding protein; RBP-J; RBP-J kappa; RBP-JK; rbp-jkappa; Recombining binding protein suppressor of hairless; Renal carcinoma antigen NY-REN-30; suppressor of hairless homolog
Gene Aliases: AI843960; AOS3; CBF1; csl; IGKJRB; IGKJRB1; Igkrsbp; KBF2; RBP-J; RBP-J kappa; RBPJ; RBPJK; RBPSUH; SUH
UniProt ID: (Human) Q06330, (Mouse) P31266
Entrez Gene ID: (Human) 3516, (Mouse) 19664
recombinase activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
sequence-specific DNA binding
protein N-terminus binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein complex binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
somitogenesis
epithelial to mesenchymal transition
blood vessel remodeling
inflammatory response to antigenic stimulus
secondary heart field specification
outflow tract morphogenesis
endocardium morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
cardiac left ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
DNA recombination
transcription initiation from RNA polymerase II promoter
humoral immune response
Notch signaling pathway
positive regulation of transcription of Notch receptor target
negative regulation of cell proliferation
auditory receptor cell fate commitment
epidermal cell fate specification
pituitary gland development
B cell differentiation
keratinocyte differentiation
negative regulation of ossification
positive regulation of BMP signaling pathway
somatic stem cell population maintenance
dorsal aorta morphogenesis
atrioventricular canal development
defense response to bacterium
myeloid dendritic cell differentiation
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of timing of cell differentiation
sebaceous gland development
hair follicle maturation
positive regulation of cardiac muscle cell proliferation
Clara cell differentiation
labyrinthine layer blood vessel development
arterial endothelial cell fate commitment
Notch signaling involved in heart development
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
blood vessel lumenization
interleukin-4 secretion
blood vessel endothelial cell fate specification
positive regulation of ERBB signaling pathway
positive regulation of ephrin receptor signaling pathway
positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
positive regulation of cell proliferation involved in heart morphogenesis
heart looping
endocardium development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
heart development
positive regulation of cell proliferation
regulation of gene expression
positive regulation of gene expression
negative regulation of neuron projection development
negative regulation of smooth muscle cell migration
hemopoiesis
neuron differentiation
negative regulation of smooth muscle cell apoptotic process
positive regulation of Notch signaling pathway involved in heart induction
cell fate commitment
positive regulation of transcription, DNA-templated
positive regulation of smooth muscle cell proliferation
artery morphogenesis
Notch signaling pathway involved in arterial endothelial cell fate commitment
regulation of cell adhesion involved in heart morphogenesis
determination of heart left/right asymmetry
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