Invitrogen

RBPJ Recombinant Rabbit Monoclonal Antibody (ARC0894)

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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

MA5-35438

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0894

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RBPJK (Q06330)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.20 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849339

Product Specific Information

Immunogen sequence: CAFIGIGNSD QEMQQLNLEG KNYCTAKTLY ISDSDKRKHF MLSVKMFYGN SDDIGVFLSK RIKVISKPSK KKQSLKNADL CIASGTKVAL FNRLRSQTVS T

Target Information

CSL plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The protein is abundantly expressed in heart and skeletal muscle and expression is increased by passive stretch. Mutations in this gene can lead to X-linked deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CBF-1; H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; J kappa-recombination signal-binding protein; RBP-J; RBP-J kappa; RBP-JK; rbp-jkappa; Recombining binding protein suppressor of hairless; Renal carcinoma antigen NY-REN-30; suppressor of hairless homolog

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Gene Aliases: AI843960; AOS3; CBF1; csl; IGKJRB; IGKJRB1; Igkrsbp; KBF2; RBP-J; RBP-J kappa; RBPJ; RBPJK; RBPSUH; SUH

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UniProt ID: (Human) Q06330, (Mouse) P31266

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Entrez Gene ID: (Human) 3516, (Mouse) 19664

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Function(s)
recombinase activity RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II repressing transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding sequence-specific DNA binding protein N-terminus binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein complex binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis somitogenesis epithelial to mesenchymal transition blood vessel remodeling inflammatory response to antigenic stimulus secondary heart field specification outflow tract morphogenesis endocardium morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation cardiac left ventricle morphogenesis ventricular trabecula myocardium morphogenesis regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation DNA recombination transcription initiation from RNA polymerase II promoter humoral immune response Notch signaling pathway positive regulation of transcription of Notch receptor target negative regulation of cell proliferation auditory receptor cell fate commitment epidermal cell fate specification pituitary gland development B cell differentiation keratinocyte differentiation negative regulation of ossification positive regulation of BMP signaling pathway somatic stem cell population maintenance dorsal aorta morphogenesis atrioventricular canal development defense response to bacterium myeloid dendritic cell differentiation negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation sebaceous gland development hair follicle maturation positive regulation of cardiac muscle cell proliferation Clara cell differentiation labyrinthine layer blood vessel development arterial endothelial cell fate commitment Notch signaling involved in heart development positive regulation of transcription from RNA polymerase II promoter in response to hypoxia blood vessel lumenization interleukin-4 secretion blood vessel endothelial cell fate specification positive regulation of ERBB signaling pathway positive regulation of ephrin receptor signaling pathway positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment positive regulation of cell proliferation involved in heart morphogenesis heart looping endocardium development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development positive regulation of cell proliferation regulation of gene expression positive regulation of gene expression negative regulation of neuron projection development negative regulation of smooth muscle cell migration hemopoiesis neuron differentiation negative regulation of smooth muscle cell apoptotic process positive regulation of Notch signaling pathway involved in heart induction cell fate commitment positive regulation of transcription, DNA-templated positive regulation of smooth muscle cell proliferation artery morphogenesis Notch signaling pathway involved in arterial endothelial cell fate commitment regulation of cell adhesion involved in heart morphogenesis determination of heart left/right asymmetry
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