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REA Antibody (PA5-14132) in IHC (P)
Immunohistochemistry analysis of REA in formalin-fixed and paraffin-embedded Human colon carcinoma tissue. Samples were incubated with REA polyclonal antibody (Product # PA5-14132) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-14132
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 106-134 amino acids from human PHB2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2268305
Product Specific Information
This antibody is predicted to react with bovine, chicken and rat based on sequence homology.
Target Information
PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell associated protein; B-cell receptor-associated protein 37; B-cell receptor-associated protein BAP37; D-prohibitin; MGC117268; PHB2; Prohibitin-2; Repressor of estrogen receptor activity
Gene Aliases: AU044498; BAP; Bap37; BCAP37; hBAP; p22; PHB2; PNAS-141; REA
UniProt ID: (Human) Q99623, (Mouse) O35129
Entrez Gene ID: (Human) 11331, (Mouse) 12034
protein import into nucleus, translocation
transcription, DNA-templated
regulation of transcription, DNA-templated
mitochondrion organization
sister chromatid cohesion
positive regulation of exit from mitosis
negative regulation of intracellular estrogen receptor signaling pathway
negative regulation of mammary gland epithelial cell proliferation
negative regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
mammary gland branching involved in thelarche
mammary gland alveolus development
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of ERK1 and ERK2 cascade
positive regulation of cell cycle G1/S phase transition
regulation of complement activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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