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This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found.
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Protein Aliases: AIBP80; Alpha integrin-binding protein 80; DNA repair protein REV1; REV1 homolog; REV1, polymerase (DNA directed); REV1- like; Rev1-like terminal deoxycytidyl transferase
Gene Aliases: AIBP80; REV1; REV1L
UniProt ID: (Human) Q9UBZ9
Entrez Gene ID: (Human) 51455
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