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Product Details
PA5-100316
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RGN(Accession Q15493), corresponding to amino acid residues C78-E128.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2849830
Product Specific Information
Antibody detects endogenous levels of total RGN/SMP30.
Target Information
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory protein Li 41; Gluconolactonase; GNL; RC; Regucalcin; Senescence marker protein 30; SMP-30
Gene Aliases: AI265316; GNL; HEL-S-41; RC; Reguc; RGN; SMP30
UniProt ID: (Human) Q15493, (Rat) Q03336, (Mouse) Q64374
Entrez Gene ID: (Human) 9104, (Rat) 25106, (Mouse) 19733
kidney development
negative regulation of protein kinase activity
cellular calcium ion homeostasis
spermatogenesis
aging
positive regulation of triglyceride biosynthetic process
positive regulation of glucose metabolic process
positive regulation of phosphatase activity
L-ascorbic acid biosynthetic process
negative regulation of phosphoprotein phosphatase activity
positive regulation of ATPase activity
negative regulation of GTPase activity
negative regulation of apoptotic process
positive regulation of GTPase activity
negative regulation of nitric oxide biosynthetic process
positive regulation of fatty acid biosynthetic process
negative regulation of epithelial cell proliferation
regulation of calcium-mediated signaling
negative regulation of cyclic-nucleotide phosphodiesterase activity
liver regeneration
negative regulation of sperm motility
positive regulation of superoxide dismutase activity
positive regulation of calcium-transporting ATPase activity
negative regulation of RNA biosynthetic process
negative regulation of bone development
positive regulation of proteolysis involved in cellular protein catabolic process
negative regulation of calcium-dependent ATPase activity
negative regulation of DNA catabolic process
positive regulation of dUTP diphosphatase activity
negative regulation of leucine-tRNA ligase activity
negative regulation of DNA biosynthetic process
liver development
negative regulation of protein phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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