Proteintech

RGN/SMP30 Polyclonal Antibody

RGN/SMP30 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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RGN/SMP30 Antibody (17947-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using (Product # 17947-1-AP) (RGN/SMP30 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

RGN/SMP30 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17947-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:3000-1:10,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RGN/SMP30 Fusion Protein Ag12423 (1-299 aa encoded by BC073173)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSSIKIECV LPENCRCGES PVWEEVSNSL LFVDIPAKKV CRWDSFTKQV QRVTMDAPVS SVALRQSGGY VATIGTKFCA LNWKEQSAVV LATVDNDKKN NRFNDGKVDP AGRYFAGTMA EETAPAVLER HQGALYSLFP DHHVKKYFDQ VDISNGLDWS LDHKIFYYID SLSYSVDAFD YDLQTGQISN RRSVYKLEKE EQIPDGMCID AEGKLWVACY NGGRVIRLDP VTGKRLQTVK LPVDKTTSCC FGGKNYSEMY VTCARDGMDP EGLLRQPEAG GIFKITGLGV KGIAPYSYAG (1-299 aa encoded by BC073173)

Target Information

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-κB signaling pathway mediated by the DNA damage response.

Ecotoxicology and environmental safety

Ma Y,Li S,Ye S,Hu D,Wei L,Xiao F

Fri Jul 01 00:00:00 EDT 2022

Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.

Ecotoxicology and environmental safety

Ma Y,Liang Y,Liang N,Zhang Y,Xiao F

Mon Mar 15 00:00:00 EDT 2021

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.

Translational lung cancer research

Shao C,Guo K,Xu L,Zhang Y,Duan H,Feng Y,Pan M,Lu D,Ren X,Ganti AK,Hakozaki T,Han J,Yan X,Ma Z

Wed Dec 01 00:00:00 EST 2021

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.

Translational lung cancer research

Shao C,Guo K,Xu L,Zhang Y,Duan H,Feng Y,Pan M,Lu D,Ren X,Ganti AK,Hakozaki T,Han J,Yan X,Ma Z

Wed Dec 01 00:00:00 EST 2021

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.

Translational lung cancer research

Shao C,Guo K,Xu L,Zhang Y,Duan H,Feng Y,Pan M,Lu D,Ren X,Ganti AK,Hakozaki T,Han J,Yan X,Ma Z

Wed Dec 01 00:00:00 EST 2021

Senescence marker protein 30 inhibits tumor growth by reducing HDAC4 expression in non-small cell lung cancer.

Translational lung cancer research

Shao C,Guo K,Xu L,Zhang Y,Duan H,Feng Y,Pan M,Lu D,Ren X,Ganti AK,Hakozaki T,Han J,Yan X,Ma Z

Wed Dec 01 00:00:00 EST 2021

Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.

International immunopharmacology

Zhang L,Zhu T,He F,Li X

Wed Dec 01 00:00:00 EST 2021

Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine.

Gene

Okada N,Oshima K,Iwasaki Y,Maruko A,Matsumura K,Iioka E,Vu TD,Fujitsuka N,Nishi A,Sugiyama A,Nishiyama M,Kaneko A,Mizoguchi K,Yamamoto M,Nishimura S

Fri Aug 20 00:00:00 EDT 2021

A mechanism of regucalcin knock-down in the promotion of proliferation and movement of human cervical cancer HeLa cells.

Translational cancer research

Li X,Huang Y,Wang P,Song W,Yao Q,Hu Q,Zhou S

Mon Apr 01 00:00:00 EDT 2019

Exogenous regucalcin negatively regulates the progression of cervical adenocarcinoma.

Oncology letters

Li X,Huang Y,Guo S,Xie M,Bin X,Shi M,Chen A,Chen S,Wu F,Hu Q,Zhou S

Mon Jul 01 00:00:00 EDT 2019

Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows.

The Journal of endocrinology

Weitzel JM,Viergutz T,Albrecht D,Bruckmaier R,Schmicke M,Tuchscherer A,Koch F,Kuhla B

Tue Aug 01 00:00:00 EDT 2017

Hepatic thyroid signaling of heat-stressed late pregnant and early lactating cows.

The Journal of endocrinology

Weitzel JM,Viergutz T,Albrecht D,Bruckmaier R,Schmicke M,Tuchscherer A,Koch F,Kuhla B

Tue Aug 01 00:00:00 EDT 2017

Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.

Toxicology letters

Zhao X,Cong X,Zheng L,Xu L,Yin L,Peng J

Tue Oct 02 00:00:00 EDT 2012

Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.

Toxicology letters

Zhao X,Cong X,Zheng L,Xu L,Yin L,Peng J

Tue Oct 02 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: epididymis secretory protein Li 41; Gluconolactonase; GNL; RC; Regucalcin; Senescence marker protein 30; SMP-30

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Gene Aliases: AI265316; GNL; HEL-S-41; RC; Reguc; RGN; SMP30

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UniProt ID: (Human) Q15493, (Rat) Q03336, (Mouse) Q64374

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Entrez Gene ID: (Human) 9104, (Rat) 25106, (Mouse) 19733

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Function(s)

gluconolactonase activity calcium ion binding zinc ion binding enzyme regulator activity hydrolase activity metal ion binding esterase

Process(es)

kidney development negative regulation of protein kinase activity cellular calcium ion homeostasis spermatogenesis aging positive regulation of triglyceride biosynthetic process positive regulation of glucose metabolic process positive regulation of phosphatase activity L-ascorbic acid biosynthetic process negative regulation of phosphoprotein phosphatase activity positive regulation of ATPase activity negative regulation of GTPase activity negative regulation of apoptotic process positive regulation of GTPase activity negative regulation of nitric oxide biosynthetic process positive regulation of fatty acid biosynthetic process negative regulation of epithelial cell proliferation regulation of calcium-mediated signaling negative regulation of cyclic-nucleotide phosphodiesterase activity liver regeneration negative regulation of sperm motility positive regulation of superoxide dismutase activity positive regulation of calcium-transporting ATPase activity negative regulation of RNA biosynthetic process negative regulation of bone development positive regulation of proteolysis involved in cellular protein catabolic process negative regulation of calcium-dependent ATPase activity negative regulation of DNA catabolic process positive regulation of dUTP diphosphatase activity negative regulation of leucine-tRNA ligase activity negative regulation of DNA biosynthetic process liver development negative regulation of protein phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RGN/SMP30 Polyclonal Antibody

RGN/SMP30 Antibody (17947-1-AP) in IHC (P)

Product Details

17947-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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