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The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. The mRNA of the human gene is abundantly expressed in heart, lung, skeletal muscle, and small intestine, and at low levels in brain, placenta, liver, colon, and leukocytes.
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Protein Aliases: Regulator of G-protein signaling 5; RGS-5; RGS5; RP11-430G6.2
Gene Aliases: MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; RGS5
UniProt ID: (Human) O15539
Entrez Gene ID: (Human) 8490
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