Proteintech

RICTOR Polyclonal Antibody

RICTOR Antibody in Immunocytochemistry (ICC/IF)

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RICTOR Antibody (27248-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°CMethanol) fixed NIH/3T3 cells using 27248-1-AP (RICTOR antibody) at dilution of 1:200 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

RICTOR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

27248-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RICTOR Fusion Protein Ag25649 (1-51 aa encoded by BC029608)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAIGRGRS LKNLRVRGRN DSGEENVPLD LTREPSDNLR EILQNVARLQ GV (1-51 aa encoded by BC029608)

Target Information

RICTOR and MTOR (FRAP1) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification of circular dorsal ruffles as signal platforms for the AKT pathway in glomerular podocytes.

Journal of cellular physiology

Hua R,Wei J,Torres M,He Y,Li Y,Sun X,Wang L,Inoki K,Yoshida S

Mon May 01 00:00:00 EDT 2023

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice.

Materials today. Bio

Niu X,Xia Y,Luo L,Chen Y,Yuan J,Zhang J,Zheng X,Li Q,Deng Z,Wang Y

Sat Apr 01 00:00:00 EDT 2023

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice.

Materials today. Bio

Niu X,Xia Y,Luo L,Chen Y,Yuan J,Zhang J,Zheng X,Li Q,Deng Z,Wang Y

Sat Apr 01 00:00:00 EDT 2023

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice.

Materials today. Bio

Niu X,Xia Y,Luo L,Chen Y,Yuan J,Zhang J,Zheng X,Li Q,Deng Z,Wang Y

Sat Apr 01 00:00:00 EDT 2023

iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice.

Materials today. Bio

Niu X,Xia Y,Luo L,Chen Y,Yuan J,Zhang J,Zheng X,Li Q,Deng Z,Wang Y

Sat Apr 01 00:00:00 EDT 2023

Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.

Ecotoxicology and environmental safety

Li X,Wang W,Hou Y,Li G,Yi H,Cui S,Zhang J,He X,Zhao H,Yang Z,Qiu Y,Liu Z,Xie J

Thu Jun 01 00:00:00 EDT 2023

Interleukin 6 promotes BMP9-induced osteoblastic differentiation through Stat3/mTORC1 in mouse embryonic fibroblasts.

Aging

Wang SY,Jiang JH,Liu SY,Zhang J,Gao X,Liu H,Ke KX,Jiang Y,Liu L,He BC

Wed Feb 01 00:00:00 EST 2023

Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways.

Cell reports

Yasuda T,Ishihara T,Ichimura A,Ishihara N

Tue May 30 00:00:00 EDT 2023

Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways.

Cell reports

Yasuda T,Ishihara T,Ichimura A,Ishihara N

Tue May 30 00:00:00 EDT 2023

PCB153 suppressed autophagy via PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling by the upregulation of microRNA-155 in rat primary chondrocytes.

Toxicology and applied pharmacology

Liu Z,Huang Y,Jin X,Liu L,Gu H

Mon Aug 15 00:00:00 EDT 2022

Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Fang Y,Zhong T,Yang L,Luo F,Li Q,Wang D,Li Q,Fan Y,Yang X

Wed Jul 20 00:00:00 EDT 2022

Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-mediated Effects on mTORC1 and mTORC2.

Endocrinology

Fu Y,Wei Y,Zhou Y,Wu H,Hong Y,Long C,Wang J,Wu Y,Wu S,Shen L,Wei G

Fri Oct 01 00:00:00 EDT 2021

Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.

American journal of physiology. Heart and circulatory physiology

Sun Z,Zhang L,Li L,Shao C,Liu J,Zhou M,Wang Z

Fri Jan 01 00:00:00 EST 2021

TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.

Experimental cell research

Song S,Qiu D,Wang Y,Wei J,Wu H,Wu M,Wang S,Zhou X,Shi Y,Duan H

Sun Mar 15 00:00:00 EDT 2020

TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.

Experimental cell research

Song S,Qiu D,Wang Y,Wei J,Wu H,Wu M,Wang S,Zhou X,Shi Y,Duan H

Sun Mar 15 00:00:00 EDT 2020

A glycolytic shift in Schwann cells supports injured axons.

Nature neuroscience

Babetto E,Wong KM,Beirowski B

Thu Oct 01 00:00:00 EDT 2020

Rapamycin promotes endothelial-mesenchymal transition during stress-induced premature senescence through the activation of autophagy.

Cell communication and signaling : CCS

Sasaki N,Itakura Y,Toyoda M

Thu Mar 12 00:00:00 EDT 2020

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

Nature communications

Tang W,Zhou W,Xiang L,Wu X,Zhang P,Wang J,Liu G,Zhang W,Peng Y,Huang X,Cai J,Bai Y,Bai L,Zhu W,Gu H,Xiong J,Ye C,Li A,Liu S,Wang J

Fri Feb 08 00:00:00 EST 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 EDT 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 EDT 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 EDT 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 EDT 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 EDT 2019

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

Journal of cellular physiology

Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H

Sun Sep 01 00:00:00 EDT 2019

mTOR-S6K1 pathway mediates cytoophidium assembly.

Journal of genetics and genomics = Yi chuan xue bao

Sun Z,Liu JL

Fri Feb 01 00:00:00 EST 2019

Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin-Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis, Endothelial Dysfunction, and Corporal Fibrosis.

The journal of sexual medicine

Lin H,Wang T,Ruan Y,Liu K,Li H,Wang S,Li M,Liu J

Sat Sep 01 00:00:00 EDT 2018

The journal of sexual medicine

Lin H,Wang T,Ruan Y,Liu K,Li H,Wang S,Li M,Liu J

Sat Sep 01 00:00:00 EDT 2018

Bioinformatics

Protein Aliases: AVO3 homolog; DKFZp686B11164; hAVO3; mAVO3; MGC39830; pianissimo; Protein pianissimo; Rapamycin-insensitive companion of mTOR; RICTOR; RPTOR independent companion of MTOR, complex 2; TORC2-specific protein AVO3

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Gene Aliases: 4921505C17Rik; 6030405M08Rik; AVO3; AW492497; D530039E11Rik; hAVO3; KIAA1999; PIA; RICTOR

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UniProt ID: (Human) Q6R327, (Mouse) Q6QI06

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Entrez Gene ID: (Human) 253260, (Mouse) 78757

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Function(s)

protein binding enzyme activator activity protein kinase binding ribosome binding

Process(es)

positive regulation of endothelial cell proliferation multicellular organism development embryo development regulation of gene expression peptidyl-serine phosphorylation positive regulation of actin filament polymerization actin cytoskeleton reorganization TOR signaling positive regulation of TOR signaling regulation of actin cytoskeleton organization regulation of peptidyl-serine phosphorylation regulation of phosphorylation regulation of GTPase activity regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation regulation of protein kinase B signaling positive regulation of protein kinase B signaling regulation of establishment of cell polarity establishment of cell polarity establishment or maintenance of actin cytoskeleton polarity T cell costimulation positive regulation of catalytic activity phosphatidylinositol-mediated signaling

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RICTOR Polyclonal Antibody

RICTOR Antibody (27248-1-AP) in ICC/IF

Product Details

27248-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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