Product References
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers.
Nucleic acids research
Patel PS,Algouneh A,Krishnan R,Reynolds JJ,Nixon KCJ,Hao J,Lee J,Feng Y,Fozil C,Stanic M,Yerlici T,Su P,Soares F,Liedtke E,Prive G,Baider GD,Pujana MA,Mekhail K,He HH,Hakem A,Stewart GS,Hakem R
Mon May 22 00:00:00 EDT 2023
NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.
Nucleic acid therapeutics
Zhang L,Bernardo KD,Vickers TA,Tian J,Liang XH,Crooke ST
Mon Aug 01 00:00:00 EDT 2022
Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy.
Cell
Marasco LE,Dujardin G,Sousa-Luís R,Liu YH,Stigliano JN,Nomakuchi T,Proudfoot NJ,Krainer AR,Kornblihtt AR
Thu Jun 09 00:00:00 EDT 2022
DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1.
Cell reports
Lin WL,Chen JK,Wen X,He W,Zarceno GA,Chen Y,Chen S,Paull TT,Liu HW
Tue Jul 19 00:00:00 EDT 2022
The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs.
Nucleic acid therapeutics
Zhang L,Liang XH,De Hoyos CL,Migawa M,Nichols JG,Freestone G,Tian J,Seth PP,Crooke ST
Sat Oct 01 00:00:00 EDT 2022
METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability.
Nucleic acids research
Chen L,Zhang C,Ma W,Huang J,Zhao Y,Liu H
Fri Nov 11 00:00:00 EST 2022
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Nature communications
Liu Y,Iqbal A,Li W,Ni Z,Wang Y,Ramprasad J,Abraham KJ,Zhang M,Zhao DY,Qin S,Loppnau P,Jiang H,Guo X,Brown PJ,Zhen X,Xu G,Mekhail K,Ji X,Bedford MT,Greenblatt JF,Min J
Fri Sep 16 00:00:00 EDT 2022
Protocol to use RNaseH1-based CRISPR to modulate locus-associated R-loops.
STAR protocols
Khosraviani N,Abraham KJ,Chan JNY,Mekhail K
Fri Dec 16 00:00:00 EST 2022
R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage.
Science advances
Chatzidoukaki O,Stratigi K,Goulielmaki E,Niotis G,Akalestou-Clocher A,Gkirtzimanaki K,Zafeiropoulos A,Altmüller J,Topalis P,Garinis GA
Fri Nov 19 00:00:00 EST 2021
RTEL1 influences the abundance and localization of TERRA RNA.
Nature communications
Ghisays F,Garzia A,Wang H,Canasto-Chibuque C,Hohl M,Savage SA,Tuschl T,Petrini JHJ
Fri May 21 00:00:00 EDT 2021
Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Nucleic acids research
Vasquez G,Freestone GC,Wan WB,Low A,De Hoyos CL,Yu J,Prakash TP,¿stergaard ME,Liang XH,Crooke ST,Swayze EE,Migawa MT,Seth PP
Fri Feb 26 00:00:00 EST 2021
ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.
Nature communications
Jimeno S,Prados-Carvajal R,Fernández-Ávila MJ,Silva S,Silvestris DA,Endara-Coll M,Rodríguez-Real G,Domingo-Prim J,Mejías-Navarro F,Romero-Franco A,Jimeno-González S,Barroso S,Cesarini V,Aguilera A,Gallo A,Visa N,Huertas P
Fri Sep 17 00:00:00 EDT 2021
Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells.
Cell research
Wu J,Wu C,Xing F,Cao L,Zeng W,Guo L,Li P,Zhong Y,Jiang H,Luo M,Shi G,Bu L,Ji Y,Hou P,Peng H,Huang J,Li C,Guo D
Wed Sep 01 00:00:00 EDT 2021
RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
The Journal of clinical investigation
Patel PS,Abraham KJ,Guturi KKN,Halaby MJ,Khan Z,Palomero L,Ho B,Duan S,St-Germain J,Algouneh A,Mateo F,El Ghamrasni S,Barbour H,Barnes DR,Beesley J,Sanchez O,Berman HK,Brown GW,Affar EB,Chenevix-Trench G,Antoniou AC,Arrowsmith CH,Raught B,Pujana MA,Mekhail K,Hakem A,Hakem R
Mon Feb 01 00:00:00 EST 2021
Short DNA/RNA heteroduplex oligonucleotide interacting proteins are key regulators of target gene silencing.
Nucleic acids research
Asada K,Sakaue F,Nagata T,Zhang JC,Yoshida-Tanaka K,Abe A,Nawa M,Nishina K,Yokota T
Fri May 21 00:00:00 EDT 2021
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.
Science advances
Jiang M,Xie X,Zhu X,Jiang S,Milenkovic D,Misic J,Shi Y,Tandukar N,Li X,Atanassov I,Jenninger L,Hoberg E,Albarran-Gutierrez S,Szilagyi Z,Macao B,Siira SJ,Carelli V,Griffith JD,Gustafsson CM,Nicholls TJ,Filipovska A,Larsson NG,Falkenberg M
Thu Jul 01 00:00:00 EDT 2021
Mutual Balance of Histone Deacetylases 1 and 2 and the Acetyl Reader ATAD2 Regulates the Level of Acetylation of Histone H4 on Nascent Chromatin of Human Cells.
Molecular and cellular biology
Lazarchuk P,Hernandez-Villanueva J,Pavlova MN,Federation A,MacCoss M,Sidorova JM
Mon Apr 13 00:00:00 EDT 2020
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.
Molecular cell
Zhang C,Chen L,Peng D,Jiang A,He Y,Zeng Y,Xie C,Zhou H,Luo X,Liu H,Chen L,Ren J,Wang W,Zhao Y
Thu Aug 06 00:00:00 EDT 2020
The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability.
Molecular cancer research : MCR
Tumini E,Herrera-Moyano E,San Martín-Alonso M,Barroso S,Galmarini CM,Aguilera A
Fri Mar 01 00:00:00 EST 2019
The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability.
Molecular cancer research : MCR
Tumini E,Herrera-Moyano E,San Martín-Alonso M,Barroso S,Galmarini CM,Aguilera A
Fri Mar 01 00:00:00 EST 2019
Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer.
PLoS genetics
Deasy SK,Uehara R,Vodnala SK,Yang HH,Dass RA,Hu Y,Lee MP,Crouch RJ,Hunter KW
Wed May 01 00:00:00 EDT 2019
BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells.
Nucleic acids research
Chiang HC,Zhang X,Li J,Zhao X,Chen J,Wang HT,Jatoi I,Brenner A,Hu Y,Li R
Tue Jun 04 00:00:00 EDT 2019
BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells.
Nucleic acids research
Chiang HC,Zhang X,Li J,Zhao X,Chen J,Wang HT,Jatoi I,Brenner A,Hu Y,Li R
Tue Jun 04 00:00:00 EDT 2019
FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops.
Scientific reports
Pan X,Chen Y,Biju B,Ahmed N,Kong J,Goldenberg M,Huang J,Mohan N,Klosek S,Parsa K,Guh CY,Lu R,Pickett HA,Chu HP,Zhang D
Fri Dec 13 00:00:00 EST 2019
EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
Nature
Gorthi A,Romero JC,Loranc E,Cao L,Lawrence LA,Goodale E,Iniguez AB,Bernard X,Masamsetti VP,Roston S,Lawlor ER,Toretsky JA,Stegmaier K,Lessnick SL,Chen Y,Bishop AJR
Thu Mar 15 00:00:00 EDT 2018
EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
Nature
Gorthi A,Romero JC,Loranc E,Cao L,Lawrence LA,Goodale E,Iniguez AB,Bernard X,Masamsetti VP,Roston S,Lawlor ER,Toretsky JA,Stegmaier K,Lessnick SL,Chen Y,Bishop AJR
Thu Mar 15 00:00:00 EDT 2018
Chromatin conformation regulates the coordination between DNA replication and transcription.
Nature communications
Almeida R,Fernández-Justel JM,Santa-María C,Cadoret JC,Cano-Aroca L,Lombraña R,Herranz G,Agresti A,Gómez M
Mon Apr 23 00:00:00 EDT 2018
Chromatin conformation regulates the coordination between DNA replication and transcription.
Nature communications
Almeida R,Fernández-Justel JM,Santa-María C,Cadoret JC,Cano-Aroca L,Lombraña R,Herranz G,Agresti A,Gómez M
Mon Apr 23 00:00:00 EDT 2018
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
F1000Research
Bhatia V,Valdés-Sánchez L,Rodriguez-Martinez D,Bhattacharya SS
Tue Nov 19 00:00:00 EST 2019
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
F1000Research
Bhatia V,Valdés-Sánchez L,Rodriguez-Martinez D,Bhattacharya SS
Tue Nov 19 00:00:00 EST 2019
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
F1000Research
Bhatia V,Valdés-Sánchez L,Rodriguez-Martinez D,Bhattacharya SS
Tue Nov 19 00:00:00 EST 2019
Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice.
F1000Research
Bhatia V,Valdés-Sánchez L,Rodriguez-Martinez D,Bhattacharya SS
Tue Nov 19 00:00:00 EST 2019
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
Nature cell biology
Michelini F,Pitchiaya S,Vitelli V,Sharma S,Gioia U,Pessina F,Cabrini M,Wang Y,Capozzo I,Iannelli F,Matti V,Francia S,Shivashankar GV,Walter NG,d'Adda di Fagagna F
Fri Dec 01 00:00:00 EST 2017
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
Nature cell biology
Michelini F,Pitchiaya S,Vitelli V,Sharma S,Gioia U,Pessina F,Cabrini M,Wang Y,Capozzo I,Iannelli F,Matti V,Francia S,Shivashankar GV,Walter NG,d'Adda di Fagagna F
Fri Dec 01 00:00:00 EST 2017
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Nature communications
Zhang X,Chiang HC,Wang Y,Zhang C,Smith S,Zhao X,Nair SJ,Michalek J,Jatoi I,Lautner M,Oliver B,Wang H,Petit A,Soler T,Brunet J,Mateo F,Angel Pujana M,Poggi E,Chaldekas K,Isaacs C,Peshkin BN,Ochoa O,Chedin F,Theoharis C,Sun LZ,Curiel TJ,Elledge R,Jin VX,Hu Y,Li R
Mon Jun 26 00:00:00 EDT 2017
Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis.
Nature communications
Zhang X,Chiang HC,Wang Y,Zhang C,Smith S,Zhao X,Nair SJ,Michalek J,Jatoi I,Lautner M,Oliver B,Wang H,Petit A,Soler T,Brunet J,Mateo F,Angel Pujana M,Poggi E,Chaldekas K,Isaacs C,Peshkin BN,Ochoa O,Chedin F,Theoharis C,Sun LZ,Curiel TJ,Elledge R,Jin VX,Hu Y,Li R
Mon Jun 26 00:00:00 EDT 2017
Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids.
Nucleic acids research
Abraham KJ,Chan JN,Salvi JS,Ho B,Hall A,Vidya E,Guo R,Killackey SA,Liu N,Lee JE,Brown GW,Mekhail K
Fri Oct 14 00:00:00 EDT 2016
Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids.
Nucleic acids research
Abraham KJ,Chan JN,Salvi JS,Ho B,Hall A,Vidya E,Guo R,Killackey SA,Liu N,Lee JE,Brown GW,Mekhail K
Fri Oct 14 00:00:00 EDT 2016
Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids.
Nucleic acids research
Abraham KJ,Chan JN,Salvi JS,Ho B,Hall A,Vidya E,Guo R,Killackey SA,Liu N,Lee JE,Brown GW,Mekhail K
Fri Oct 14 00:00:00 EDT 2016
Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids.
Nucleic acids research
Abraham KJ,Chan JN,Salvi JS,Ho B,Hall A,Vidya E,Guo R,Killackey SA,Liu N,Lee JE,Brown GW,Mekhail K
Fri Oct 14 00:00:00 EDT 2016
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Hill SJ,Mordes DA,Cameron LA,Neuberg DS,Landini S,Eggan K,Livingston DM
Tue Nov 29 00:00:00 EST 2016
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.
Proceedings of the National Academy of Sciences of the United States of America
Hill SJ,Mordes DA,Cameron LA,Neuberg DS,Landini S,Eggan K,Livingston DM
Tue Nov 29 00:00:00 EST 2016
Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.
Scientific reports
Kasuya T,Hori S,Watanabe A,Nakajima M,Gahara Y,Rokushima M,Yanagimoto T,Kugimiya A
Wed Jul 27 00:00:00 EDT 2016
Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides.
Scientific reports
Kasuya T,Hori S,Watanabe A,Nakajima M,Gahara Y,Rokushima M,Yanagimoto T,Kugimiya A
Wed Jul 27 00:00:00 EDT 2016
XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides.
Biochemical and biophysical research communications
Hori S,Yamamoto T,Obika S
Fri Aug 21 00:00:00 EDT 2015
XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides.
Biochemical and biophysical research communications
Hori S,Yamamoto T,Obika S
Fri Aug 21 00:00:00 EDT 2015
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.
PLoS genetics
García-Rubio ML,Pérez-Calero C,Barroso SI,Tumini E,Herrera-Moyano E,Rosado IV,Aguilera A
Sun Nov 01 00:00:00 EDT 2015
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops.
PLoS genetics
García-Rubio ML,Pérez-Calero C,Barroso SI,Tumini E,Herrera-Moyano E,Rosado IV,Aguilera A
Sun Nov 01 00:00:00 EDT 2015
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.
Nature
Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A
Thu Jul 17 00:00:00 EDT 2014
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.
Nature
Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A
Thu Jul 17 00:00:00 EDT 2014
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.
Genes & development
Hill SJ,Rolland T,Adelmant G,Xia X,Owen MS,Dricot A,Zack TI,Sahni N,Jacob Y,Hao T,McKinney KM,Clark AP,Reyon D,Tsai SQ,Joung JK,Beroukhim R,Marto JA,Vidal M,Gaudet S,Hill DE,Livingston DM
Mon Sep 01 00:00:00 EDT 2014
The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.
Genes & development
Herrera-Moyano E,Mergui X,García-Rubio ML,Barroso S,Aguilera A
Tue Apr 01 00:00:00 EDT 2014
The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts.
Genes & development
Herrera-Moyano E,Mergui X,García-Rubio ML,Barroso S,Aguilera A
Tue Apr 01 00:00:00 EDT 2014
