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The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling. This complex is involved in the regulation of late endosomal traffic and cellular proliferation and plays a role in cellular host defense against Salmonella infection.
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Protein Aliases: Endosomal adaptor protein p14; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2; late endosomal/lysosomal MP1 interacting protein; Late endosomal/lysosomal Mp1-interacting protein; MAPBP-interacting protein; MAPKSP1 adaptor protein; mitogen activated protein binding protein interacting protein; mitogen-activated protein binding protein interacting protein; Mitogen-activated protein-binding protein-interacting protein; mitogen-activated protein-binding protein-interacting protein (MAPBPIP); Ragulator complex protein LAMTOR2; roadblock domain containing 3; Roadblock domain-containing protein 3
Gene Aliases: 2010111E04Rik; AL022628; ENDAP; HSPC003; LAMTOR2; MAPBPIP; MAPKSP1AP; P14; Rab25; Ragulator2; RGD1562501; ROBLD3
UniProt ID: (Human) Q9Y2Q5, (Mouse) Q9JHS3
Entrez Gene ID: (Human) 28956, (Mouse) 83409, (Rat) 295234
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