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NeoBiotechnologies
ROR-gamma/RORC (RAR-related Orphan Receptor C) Recombinant Rabbit Monoclonal Antibody (RORC/8278R)
Product Details
6097-RBM10-P1
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
RORC/8278R
Immunogen
Recombinant full-length human ROR gamma T protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: Human pancreas liver or skeletal muscle tissue.
Cellular Location: Nucleus.
Target Information
ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma
Gene Aliases: IMD42; NR1F3; RORC; RORG; RZR-GAMMA; RZRG; TOR
UniProt ID: (Human) P51449
Entrez Gene ID: (Human) 6097
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding
C4 zinc finger nuclear receptor
transcription initiation from RNA polymerase II promoter
xenobiotic metabolic process
regulation of glucose metabolic process
regulation of steroid metabolic process
intracellular receptor signaling pathway
circadian regulation of gene expression
cellular response to sterol
positive regulation of circadian rhythm
steroid hormone mediated signaling pathway
regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
adipose tissue development
regulation of transcription involved in cell fate commitment
T-helper 17 cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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