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Product Details
PA5-86733
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 114-159 of Human RORgamma.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2803493
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches. It has been shown that ROR gamma(t), a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas.
ROR gammat t (RORgt) is an isoform of RORC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC129539; Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan nuclear receptor variant 2; RAR-related orphan receptor C; RAR-related orphan receptor C, isoform a; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; ROR Gamma; ROR gamma t; RORgt; RP11-98D18.11-001; Thymus orphan receptor; TOR
Gene Aliases: IMD42; NR1F3; RORC; RORG; RORgamma; RZR-GAMMA; RZRG; Thor; TOR
UniProt ID: (Human) P51449, (Mouse) P51450
Entrez Gene ID: (Human) 6097, (Rat) 368158, (Mouse) 19885
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding
molecular_function
DNA binding
transcription coactivator binding
metal ion binding
C4 zinc finger nuclear receptor
transcription initiation from RNA polymerase II promoter
xenobiotic metabolic process
regulation of glucose metabolic process
regulation of steroid metabolic process
intracellular receptor signaling pathway
circadian regulation of gene expression
cellular response to sterol
positive regulation of circadian rhythm
steroid hormone mediated signaling pathway
regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
adipose tissue development
regulation of transcription involved in cell fate commitment
T-helper 17 cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
circadian rhythm
protein phosphorylation
multicellular organism development
cell differentiation
interleukin-17 production
T cell differentiation in thymus
T-helper cell differentiation
regulation of gamma-delta T cell differentiation
alpha-beta T cell differentiation
rhythmic process
lymph node development
mucosal-associated lymphoid tissue development
Peyer's patch development
negative regulation of thymocyte apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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