Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Immunogen sequence: IENLPAFPRE KLTLRLLLGS GAFGEVYEGT AVDILGVGSG EIKVAVKTLK KGSTDQEKIE FLKEAHLMSK FNHPNILKQL GVCLLNEPQY IILELMEGGD LLTYLRKARM ATFYGPLLTL VDLVDLCVDI SKGCVYLERM HFIHRDLAAR NCLVSVKDYT SPRIVKIGDF GLARDIYKND YYRKRGEGLL PVRWMAPESL MDGIFTTQSD VWSFGILIWE ILTLGHQPYP AHSNLDVLNY VQTGGRLEPP RNCPDDLWNL MTQCWAQEPD QRPTFHRIQD QLQLFRNFFL NSIYKSRDE
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1; ROS proto-oncogene 1 , receptor tyrosine kinase; RP1-179P9.1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1
Gene Aliases: c-ros; c-ros-1; MCF3; ROS; Ros-1; ROS1
UniProt ID: (Human) P08922, (Mouse) Q78DX7
Entrez Gene ID: (Human) 6098, (Mouse) 19886
Molecular Function:
transmembrane signal receptor
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support