Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 4
RPS3 Antibody (PA5-76662) in IHC (P)
Immunohistochemistry analysis of RPS3 in paraffin-embedded mouse pancreas. Samples were incubated with RPS3 polyclonal antibody (Product # PA5-76662) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
PA5-76662
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human RPS3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2720389
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 40S ribosomal protein S3; FLJ26283; FLJ27450; IMR-90 ribosomal protein S3; MGC87870; OTTHUMP00000229804; OTTHUMP00000229805; OTTHUMP00000229874; OTTHUMP00000229877; OTTHUMP00000229878; OTTHUMP00000229879; OTTHUMP00000229880; OTTHUMP00000229882; OTTHUMP00000229883; OTTHUMP00000229886; Small ribosomal subunit protein uS3
Gene Aliases: D7Ertd795e; OK/SW-cl.26; RPS3; Rs_3; S3
UniProt ID: (Human) P23396, (Mouse) P62908, (Rat) P62909
Entrez Gene ID: (Human) 6188, (Mouse) 27050, (Rat) 140654
DNA binding
damaged DNA binding
RNA binding
mRNA binding
structural constituent of ribosome
DNA-(apurinic or apyrimidinic site) lyase activity
endodeoxyribonuclease activity
protein binding
microtubule binding
transcription factor binding
tubulin binding
DNA N-glycosylase activity
enzyme binding
kinase binding
protein kinase binding
Hsp70 protein binding
SUMO binding
oxidized purine DNA binding
oxidized pyrimidine DNA binding
ubiquitin-like protein conjugating enzyme binding
poly(A) RNA binding
protein kinase A binding
iron-sulfur cluster binding
Hsp90 protein binding
small ribosomal subunit rRNA binding
supercoiled DNA binding
nucleic acid binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
lyase activity
NF-kappaB binding
ribosomal protein
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
DNA repair
transcription, DNA-templated
regulation of transcription, DNA-templated
rRNA processing
translation
translational initiation
SRP-dependent cotranslational protein targeting to membrane
apoptotic process
cellular response to DNA damage stimulus
response to oxidative stress
chromosome segregation
mitotic nuclear division
positive regulation of gene expression
negative regulation of translation
viral transcription
positive regulation of microtubule polymerization
negative regulation of protein ubiquitination
positive regulation of endodeoxyribonuclease activity
DNA damage response, detection of DNA damage
regulation of apoptotic process
positive regulation of JUN kinase activity
negative regulation of DNA repair
positive regulation of DNA repair
spindle assembly
cell division
response to TNF agonist
cellular response to hydrogen peroxide
positive regulation of NIK/NF-kappaB signaling
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of DNA N-glycosylase activity
positive regulation of base-excision repair
positive regulation of apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
DNA metabolic process
regulation of translation
cell cycle
positive regulation of NF-kappaB transcription factor activity
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
cytoplasmic translation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support