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Product Details
PA5-83806
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RSF1. Recombinant protein control fragment (Product #RP-106109).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2790958
Product Specific Information
Immunogen sequence: KYLCECQFDD NLKFKNIINE EDADTMRLQP IGRDKDGLMY WYQLDQDHNV RMYIEEQDDQ DGSSWKCIVR NRNELAETLA LLKAQIDPVL LK
Target Information
RSF1 is required for assembly of regular nucleosome arrays by the RSF chromatin remodelling complex. Rsf1 facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappaB transcription activation. Rsf1 represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain. Rsf1 interacts with SMARCA5/SNF2H to form the RSF complex and also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HBV pX associated protein-8; HBV pX-associated protein 8; hepatitis B virus x associated protein; Hepatitis B virus X-associated protein; p325 subunit of RSF chromatin-remodeling complex; Remodeling and spacing factor 1; Rsf-1
Gene Aliases: HBXAP; p325; RSF-1; RSF1; XAP8
UniProt ID: (Human) Q96T23
Entrez Gene ID: (Human) 51773
nucleosome assembly
chromatin remodeling
DNA-templated transcription, initiation
covalent chromatin modification
nucleosome positioning
CENP-A containing nucleosome assembly
negative regulation of DNA binding
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of viral transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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