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Product Details
PA5-40081
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant drosophila Rtf1 (Rtf1, Paf1/RNA polymerase II complex component, homolog) protein.
Conjugate
Form
Liquid
Concentration
1.8 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.05% ProClin 300, 0.05% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576476
Target Information
Three isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CG10955-PA; CG10955-PB; dRtf1; RNA polymerase-associated protein Rtf1; Rtf1-PA; Rtf1-PB
Gene Aliases: CG10955; Dmel\CG10955; Dmel_CG10955; dRtf1; Rtf1
UniProt ID: (Fruit fly) Q9W261
Entrez Gene ID: (Fruit fly) 37554
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