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Product Details
MA1-06815
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
RNL-4
Immunogen
Synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of reticulon-1C.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
purified
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2285730
Product Specific Information
MA1-06815 detects reticulon-1C(NSP-C) in human, porcine, and rat samples.
MA1-06815 has sucessfully been used in flow cytometry, Western blotting, immunocytochemistry and immunohistochemistry procedures. By Western blot it detects a ~23 kDa band representing reticulon-1C.
The MA1-06815 immunogen is a synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of reticulon-1C.
Target Information
Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 0710005K15Rik; 4930441F12Rik; MGC133250; MGC40985; Neuroendocrine-specific protein; R75279; Reticulon-1; RP23-450G14.1; Rtn1-a; Rtn1-b; Rtn1-c; S-rex
Gene Aliases: NSP; RTN1
UniProt ID: (Human) Q16799, (Rat) Q64548
Entrez Gene ID: (Human) 6252, (Pig) 100152394, (Rat) 116644
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