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Product Details
PA5-79944
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of mouse RUNX3 (186-205aa QKIEDQTKAFPDRFGDLRMR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2747059
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acute myeloid leukemia 2 protein; CBF-alpha 3; CBF-alpha-3; core binding factor alpha 3; core-binding factor subunit alpha-3; oncogene AML-2; PEA2-alpha C; PEBP2-alpha C; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; Runt related transcription factor 3; runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2/CBFA3
Gene Aliases: AML2; Cbfa3; Pebp2a3
Entrez Gene ID: (Mouse) 12399, (Rat) 156726
negative regulation of transcription from RNA polymerase II promoter
ossification
chondrocyte differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
axon guidance
hemopoiesis
neuron differentiation
hair follicle morphogenesis
neuron projection development
interferon-gamma production
mRNA transcription from RNA polymerase II promoter
regulation of cell differentiation
negative regulation of cell cycle
cell maturation
negative regulation of epithelial cell proliferation
positive regulation of extrinsic apoptotic signaling pathway
biological_process
Performance Guarantee
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