Proteintech

RXRA Polyclonal Antibody

RXRA Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

RXRA Antibody (21218-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using RXRA antibody 21218-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

RXRA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RXRA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21218-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

ChIP assay (ChIP)

View 4 publications 4 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RXRA Fusion Protein Ag15651 (113-462 aa encoded by BC110998)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against the 350 AA of human RXRA C-terminal. RXRA is highly expressed in liver, also expressed in lung, kidney and heart. It specifically recognizes the 51 kDa human RXRA protein.

Immunogen sequence: LNGVLKVPA HPSGNMASFT KHICAICGDR SSGKHYGVYS CEGCKGFFKR TVRKDLTYTC RDNKDCLIDK RQRNRCQYCR YQKCLAMGMK REAVQEERQR GKDRNENEVE STSSANEDMP VERILEAELA VEPKTETYVE ANMGLNPSSP NDPVTNICQA ADKQLFTLVE WAKRIPHFSE LPLDDQVILL RAGWNELLIA SFSHRSIAVK DGILLATGLH VHRNSAHSAG VGAIFDRVLT ELVSKMRDMQ MDKTELGCLR AIVLFNPDSK GLSNPAEVEA LREKVYASLE AYCKHKYPEQ PGRFAKLLLR LPALRSIGLK CLEHLFFFKL IGDTPIDTFL MEMLEAPHQM T (113-462 aa encoded by BC110998)

Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

γ-Linolenic acid in maternal milk drives cardiac metabolic maturation.

Nature

Paredes A,Justo-Méndez R,Jiménez-Blasco D,Núñez V,Calero I,Villalba-Orero M,Alegre-Martí A,Fischer T,Gradillas A,Sant'Anna VAR,Were F,Huang Z,Hernansanz-Agustín P,Contreras C,Martínez F,Camafeita E,Vázquez J,Ruiz-Cabello J,Area-Gómez E,Sánchez-Cabo F,Treuter E,Bolaños JP,Estébanez-Perpiñá E,Rupérez FJ,Barbas C,Enríquez JA,Ricote M

Thu Jun 01 00:00:00 EDT 2023

A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.

International journal of molecular sciences

Pan Z,Chen X,Wu D,Li X,Gao W,Li G,Du G,Zhang C,Jin S,Geng Z

Sat Jan 07 00:00:00 EST 2023

A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression.

International journal of molecular sciences

Pan Z,Chen X,Wu D,Li X,Gao W,Li G,Du G,Zhang C,Jin S,Geng Z

Sat Jan 07 00:00:00 EST 2023

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ma L,Shao M,Cheng W,Jiang J,Chen X,Tan N,Ling G,Yang Y,Wang Q,Yang R,Li C,Wang Y

Sat Jul 01 00:00:00 EDT 2023

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ma L,Shao M,Cheng W,Jiang J,Chen X,Tan N,Ling G,Yang Y,Wang Q,Yang R,Li C,Wang Y

Sat Jul 01 00:00:00 EDT 2023

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ma L,Shao M,Cheng W,Jiang J,Chen X,Tan N,Ling G,Yang Y,Wang Q,Yang R,Li C,Wang Y

Sat Jul 01 00:00:00 EDT 2023

Neocryptotanshinone ameliorates insufficient energy production in heart failure by targeting retinoid X receptor alpha.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Ma L,Shao M,Cheng W,Jiang J,Chen X,Tan N,Ling G,Yang Y,Wang Q,Yang R,Li C,Wang Y

Sat Jul 01 00:00:00 EDT 2023

Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.

Acta pharmacologica Sinica

Zhang HF,Liu HM,Xiang JY,Zhou XC,Wang D,Chen RY,Tan WL,Liang LQ,Liu LL,Shi MJ,Zhang F,Xiao Y,Zhou YX,Zhang T,Tang L,Guo B,Wang YY

Mon May 01 00:00:00 EDT 2023

Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.

Acta pharmacologica Sinica

Zhang HF,Liu HM,Xiang JY,Zhou XC,Wang D,Chen RY,Tan WL,Liang LQ,Liu LL,Shi MJ,Zhang F,Xiao Y,Zhou YX,Zhang T,Tang L,Guo B,Wang YY

Mon May 01 00:00:00 EDT 2023

Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis.

BMC medicine

Zheng Z,Wu M,Li H,Xu W,Yang M,Pan K,Ni Y,Jiang T,Zheng H,Jin X,Zhang Y,Ding L,Fu J

Mon Apr 03 00:00:00 EDT 2023

Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.

Urolithiasis

Huang L,Shi Y,Hu J,Ding J,Guo Z,Yu B

Fri Dec 09 00:00:00 EST 2022

Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.

Antioxidants & redox signaling

Lv WH,Zhao T,Pantopoulos K,Chen GH,Wei XL,Zhang DG,Luo Z

Thu Sep 01 00:00:00 EDT 2022

Divergent transcriptional regulation of astrocyte reactivity across disorders.

Nature

Burda JE,O'Shea TM,Ao Y,Suresh KB,Wang S,Bernstein AM,Chandra A,Deverasetty S,Kawaguchi R,Kim JH,McCallum S,Rogers A,Wahane S,Sofroniew MV

Wed Jun 01 00:00:00 EDT 2022

Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis.

Lab animal

Huang C,Yang C,Pang D,Li C,Gong H,Cao X,He X,Chen X,Mu B,Cui Y,Liu W,Luo Q,Cheng A,Jia L,Chen M,Xiao B,Chen Z

Sun May 01 00:00:00 EDT 2022

Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis.

Chinese medicine

Qi W,Li X,Ren Y,Liu X,Fu H,Wang X,Li X,Xiong J,Zheng Q,Cai D,Liang F

Tue May 17 00:00:00 EDT 2022

Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhang L,Yan J,Liu J,Meng C,Liu F,Xia C

Fri Jul 01 00:00:00 EDT 2022

Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhang L,Yan J,Liu J,Meng C,Liu F,Xia C

Fri Jul 01 00:00:00 EDT 2022

Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells.

The international journal of biochemistry & cell biology

Chen X,Wang L,Yu X,Wang S,Zhang J

Sun Aug 01 00:00:00 EDT 2021

Caveolin-1 facilitates cell migration by upregulating nuclear receptor 4A2/retinoid X receptor α-mediated β-galactoside α2,6-sialyltransferase I expression in human hepatocarcinoma cells.

The international journal of biochemistry & cell biology

Chen X,Wang L,Yu X,Wang S,Zhang J

Sun Aug 01 00:00:00 EDT 2021

Comprehensive characterization of protein-protein interactions perturbed by disease mutations.

Nature genetics

Cheng F,Zhao J,Wang Y,Lu W,Liu Z,Zhou Y,Martin WR,Wang R,Huang J,Hao T,Yue H,Ma J,Hou Y,Castrillon JA,Fang J,Lathia JD,Keri RA,Lightstone FC,Antman EM,Rabadan R,Hill DE,Eng C,Vidal M,Loscalzo J

Mon Mar 01 00:00:00 EST 2021

Oscillating lncRNA Platr4 regulates NLRP3 inflammasome to ameliorate nonalcoholic steatohepatitis in mice.

Theranostics

Lin Y,Wang S,Gao L,Zhou Z,Yang Z,Lin J,Ren S,Xing H,Wu B

Thu Aug 05 00:00:00 EDT 2021

GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling.

Biomolecules

Juin SK,Pushpakumar S,Sen U

Thu Oct 07 00:00:00 EDT 2021

Heparin-binding growth factor (HDGF) drives radioresistance in breast cancer by activating the STAT3 signaling pathway.

Journal of translational medicine

Qiu L,Ma Y,Chen X,Zhou L,Zhang H,Zhong G,Zhang L,Tang J

Tue Aug 10 00:00:00 EDT 2021

Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia.

American journal of physiology. Lung cellular and molecular physiology

Gelfand CA,Sakurai R,Wang Y,Liu Y,Segal R,Rehan VK

Tue Sep 01 00:00:00 EDT 2020

High-Dose Dexamethasone Manipulates the Tumor Microenvironment and Internal Metabolic Pathways in Anti-Tumor Progression.

International journal of molecular sciences

Xu L,Xia H,Ni D,Hu Y,Liu J,Qin Y,Zhou Q,Yi Q,Xie Y

Sat Mar 07 00:00:00 EST 2020

Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway.

Drug design, development and therapy

Xiang S,Chen K,Xu L,Wang T,Guo C

Tue Dec 22 00:00:00 EST 2020

Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.

Science advances

Wang L,Cheng CM,Qin J,Xu M,Kao CY,Shi J,You E,Gong W,Rosa LP,Chase P,Scampavia L,Madoux F,Spicer T,Hodder P,Xu HE,Tsai SY,Tsai MJ

Fri May 01 00:00:00 EDT 2020

Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis.

Human reproduction (Oxford, England)

Kataoka H,Mori T,Okimura H,Matsushima H,Ito F,Koshiba A,Tanaka Y,Akiyama K,Maeda E,Sugahara T,Tarumi Y,Kusuki I,Khan KN,Kitawaki J

Tue Jun 04 00:00:00 EDT 2019

Activation of Pregnane X Receptor-Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo.

Drug metabolism and disposition: the biological fate of chemicals

Wang F,Wang H,Wu Y,Wang L,Zhang L,Ye X,Peng D,Chen W

Thu Aug 01 00:00:00 EDT 2019

Activation of Pregnane X Receptor-Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo.

Drug metabolism and disposition: the biological fate of chemicals

Wang F,Wang H,Wu Y,Wang L,Zhang L,Ye X,Peng D,Chen W

Thu Aug 01 00:00:00 EDT 2019

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.

Neurobiology of disease

He J,Liu H,Zhong J,Guo Z,Wu J,Zhang H,Huang Z,Jiang L,Li H,Zhang Z,Liu L,Wu Y,Qi L,Sun X,Cheng C

Sat Sep 01 00:00:00 EDT 2018

Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.

Neurobiology of disease

He J,Liu H,Zhong J,Guo Z,Wu J,Zhang H,Huang Z,Jiang L,Li H,Zhang Z,Liu L,Wu Y,Qi L,Sun X,Cheng C

Sat Sep 01 00:00:00 EDT 2018

Prevention of Oxidative Stress by α-Ketoglutarate via Activation of CAR Signaling and Modulation of the Expression of Key Antioxidant-Associated Targets in Vivo and in Vitro.

Journal of agricultural and food chemistry

He L,Wu J,Tang W,Zhou X,Lin Q,Luo F,Yin Y,Li T

Wed Oct 31 00:00:00 EDT 2018

LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.

Cell death & disease

Tang J,Zhong G,Zhang H,Yu B,Wei F,Luo L,Kang Y,Wu J,Jiang J,Li Y,Wu S,Jia Y,Liang X,Bi A

Wed Dec 05 00:00:00 EST 2018

LncRNA DANCR upregulates PI3K/AKT signaling through activating serine phosphorylation of RXRA.

Cell death & disease

Tang J,Zhong G,Zhang H,Yu B,Wei F,Luo L,Kang Y,Wu J,Jiang J,Li Y,Wu S,Jia Y,Liang X,Bi A

Wed Dec 05 00:00:00 EST 2018

Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lu C,Xu W,Zheng S

Wed Nov 01 00:00:00 EDT 2017

Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lu C,Xu W,Zheng S

Wed Nov 01 00:00:00 EDT 2017

Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lu C,Xu W,Zheng S

Wed Nov 01 00:00:00 EDT 2017

Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lu C,Xu W,Zheng S

Wed Nov 01 00:00:00 EDT 2017

Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells.

International immunopharmacology

Lu C,Xu W,Shao J,Zhang F,Chen A,Zheng S

Tue Aug 01 00:00:00 EDT 2017

Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells.

International immunopharmacology

Lu C,Xu W,Shao J,Zhang F,Chen A,Zheng S

Tue Aug 01 00:00:00 EDT 2017

Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.

Cancer research

Cui M,Xiao Z,Wang Y,Zheng M,Song T,Cai X,Sun B,Ye L,Zhang X

Sun Mar 01 00:00:00 EST 2015

Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.

Cancer research

Cui M,Xiao Z,Wang Y,Zheng M,Song T,Cai X,Sun B,Ye L,Zhang X

Sun Mar 01 00:00:00 EST 2015

Activation of RAS/ERK alone is insufficient to inhibit RXRα function and deplete retinoic acid in hepatocytes.

Biochemical and biophysical research communications

Wang AG,Song YN,Chen J,Li HL,Dong JY,Cui HP,Yao L,Li XF,Gao WT,Qiu ZW,Wang FJ,Wang JY

Fri Sep 26 00:00:00 EDT 2014

Activation of RAS/ERK alone is insufficient to inhibit RXRα function and deplete retinoic acid in hepatocytes.

Biochemical and biophysical research communications

Wang AG,Song YN,Chen J,Li HL,Dong JY,Cui HP,Yao L,Li XF,Gao WT,Qiu ZW,Wang FJ,Wang JY

Fri Sep 26 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha; RXR alpha 1

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Gene Aliases: 9530071D11Rik; NR2B1; RXRA; RXRalpha1

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UniProt ID: (Human) P19793, (Mouse) P28700

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Entrez Gene ID: (Human) 6256, (Rat) 25271, (Mouse) 20181

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 9-cis retinoic acid receptor activity protein binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding protein complex binding vitamin D receptor binding retinoic acid receptor binding sequence-specific DNA binding transcription regulatory region DNA binding retinoic acid-responsive element binding protein heterodimerization activity vitamin D response element binding double-stranded DNA binding transcription factor binding metal ion binding C4 zinc finger nuclear receptor

Process(es)

negative regulation of transcription from RNA polymerase II promoter in utero embryonic development liver development maternal placenta development transcription initiation from RNA polymerase II promoter vitamin metabolic process inflammatory response midgut development embryo implantation aging cholesterol metabolic process negative regulation of cell proliferation response to selenium ion bile acid and bile salt transport modulation by virus of host morphology or physiology axon regeneration regulation of myelination response to retinoic acid cellular response to insulin stimulus response to vitamin A response to vitamin D peroxisome proliferator activated receptor signaling pathway camera-type eye development positive regulation of apoptotic process steroid hormone mediated signaling pathway cellular lipid metabolic process response to ethanol positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron retinoic acid receptor signaling pathway protein homotetramerization response to glucocorticoid ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus placenta development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development female pregnancy response to nutrient response to organic cyclic compound positive regulation of transcription, DNA-templated heart morphogenesis negative regulation of gene expression cardiac muscle cell differentiation mesenchyme development angiogenesis involved in coronary vascular morphogenesis visceral serous pericardium development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RXRA Polyclonal Antibody

RXRA Antibody (21218-1-AP) in ICC/IF

Product Details

21218-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

RNA Immunoprecipitation (RIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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