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Product Details
H00006256-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4D6
Immunogen
RXRA (AAH07925, 1 a.a. approximately 165 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Tissue lysate).
Immunogen sequence: MLGSWPARTF HPGACVSRRP SAPWKHTASG KDSPDLRFSE HGVSQEFWAG GLVAVLEMTP SPSPWGTQEG PAGMCSLWVV GWCPCRGAGV RDLVLVHAGV WCKHVCAVQR DACGESRTPA PPRKGGAVTS VLCLFLIKTF PLFSYKFASC KQVHKDPPLV KSGFE
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha
Gene Aliases: NR2B1; RXRA
UniProt ID: (Human) P19793
Entrez Gene ID: (Human) 6256
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
9-cis retinoic acid receptor activity
protein binding
zinc ion binding
enzyme binding
protein domain specific binding
chromatin DNA binding
protein complex binding
vitamin D receptor binding
retinoic acid receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoic acid-responsive element binding
protein heterodimerization activity
vitamin D response element binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
liver development
maternal placenta development
transcription initiation from RNA polymerase II promoter
vitamin metabolic process
inflammatory response
midgut development
embryo implantation
aging
cholesterol metabolic process
negative regulation of cell proliferation
response to selenium ion
bile acid and bile salt transport
modulation by virus of host morphology or physiology
axon regeneration
regulation of myelination
response to retinoic acid
cellular response to insulin stimulus
response to vitamin A
response to vitamin D
peroxisome proliferator activated receptor signaling pathway
camera-type eye development
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
cellular lipid metabolic process
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
positive regulation of translational initiation by iron
retinoic acid receptor signaling pathway
protein homotetramerization
response to glucocorticoid
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell differentiation
cardiac muscle cell proliferation
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
regulation of branching involved in prostate gland morphogenesis
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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