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Invitrogen
RyR1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
RyR1 Antibody (PA5-84288)
Relative expression in different tissues in IHC: Detection of differential expression levels of RyR1 demonstrates antibody specificity. Immunohistochemical analysis of RyR1 using anti-RyR1 Polyclonal Antibody (Product #PA5-84288), shows significant staining of RyR1 in skeletal muscle and shows minimal or weak staining in colon tissues. The relative expression levels of RyR1 within each tissue is shown usin... View More
Product Details
PA5-84288
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RYR1. Recombinant protein control fragment (Product #RP-99988).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Anitgen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2791440
Product Specific Information
Immunogen sequence: REFLHNNLHL QGKVEGSPSL RWQMALYRGV PGREEDADDP EKIVRRVQEV SAVLYYLDQT EHPYKSKK
Target Information
Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscled cells. Ryanodine receptor, ~500 kDa, can be isolated from a variety of cell types such as lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscles, cardiac muscle and brain tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: central core disease of muscle; protein phosphatase 1, regulatory subunit 137; Ryanodine receptor 1; ryanodine receptor 1 (skeletal); RYR-1; sarcoplasmic reticulum calcium release channel; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; type 1-like ryanodine receptor
Gene Aliases: CCO; MHS; MHS1; PPP1R137; RYDR; RYR; RYR-1; RYR1; SKRR
UniProt ID: (Human) P21817
Entrez Gene ID: (Human) 6261
response to hypoxia
outflow tract morphogenesis
calcium ion transport
muscle contraction
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
response to caffeine
ion transmembrane transport
skin development
ossification involved in bone maturation
skeletal muscle fiber development
release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
cellular response to caffeine
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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